All Drug Responsive Sequences

All drug-responsive elements which respond to a Guide to PHARMACOLOGY ligand ().

ID	Target	Species	Ligand	Length	Proportional length
1190	M₂ receptor	Human	[³H]QNB	303	64.7%	No
1460	A_2A receptor	Human	CGS 21680	195	59.7%	No
1467	A_2A receptor	Human	NECA	195	59.7%	No
1469	A_2A receptor	Human	[³H]CGS 21680	195	59.7%	No
1470	A_2A receptor	Human	[³H]NECA	195	59.7%	No
1490	A_2A receptor	Human	xanthine amine congener	194	58.7%	No
1491	A_2A receptor	Human	ZM-241385	250	51.0%	No
1494	A_2A receptor	Human	[³H]XAC	194	58.7%	No
1495	A_2A receptor	Human	caffeine	107	32.2%	Yes
1862	β₂-adrenoceptor	Human	(-)-adrenaline	176	37.3%	Yes
1873	β₂-adrenoceptor	Human	ICI 118551	332	67.6%	No
1879	β₂-adrenoceptor	Human	alprenolol	336	68.4%	Yes
1888	β₂-adrenoceptor	Human	timolol	335	68.2%	Yes
2181	CaS receptor	Human	Ca²⁺	8	1.1%	No
2310	CCR5	Human	[³H]maraviroc	298	71.7%	No
2313	CCR5	Human	maraviroc	298	71.7%	Yes
2478	CRF₂ receptor	Human	urocortin 1	424	87.8%	No
2633	D₃ receptor	Human	eticlopride	327	67.8%	No
2814	GABA_B receptor	Human	GABA	221	52.4%	No
2816	GABA_B receptor	Human	baclofen	285	67.6%	Yes
2817	GABA_B receptor	Human	CGP 35348	286	67.9%	No
2820	GABA_B receptor	Human	CGP 46381	286	67.9%	No
2821	GABA_B receptor	Human	CGP 54626A	286	67.9%	No
2826	GABA_B receptor	Human	SCH 50911	285	67.6%	No
2828	GABA_B receptor	Human	phaclofen	285	67.6%	No
2980	H₁ receptor	Human	doxepin	329	72.6%	Yes
3817	δ receptor	Human	naltrindole	181	43.5%	No
3818	δ receptor	Mouse	naltrindole	335	72.5%	No
3941	μ receptor	Mouse	β-FNA	334	71.8%	No
3979	NOP receptor	Human	SB 612111	203	47.6%	No
4014	P2Y₁ receptor	Human	MRS2500	318	75.3%	No
4077	P2Y₁₂ receptor	Human	2MeSADP	294	62.9%	No
4083	P2Y₁₂ receptor	Human	[³H]2MeSADP	294	62.9%	No
5496	HCN1	Mouse	cyclic AMP	72	33.8%	No
5504	HCN2	Mouse	cyclic AMP	70	34.7%	No
5505	HCN2	Mouse	cyclic GMP	65	32.0%	No
6258	Thyroid hormone receptor-α	Human	triiodothyronine	180	68.1%	Yes
6259	Thyroid hormone receptor-α	Human	T₄	175	66.2%	Yes
6261	Thyroid hormone receptor-α	Human	tiratricol	180	68.1%	No
6262	Thyroid hormone receptor-α	Human	sobetirome	176	66.0%	No
6263	Thyroid hormone receptor-α	Human	KB-141	184	69.6%	No
6265	Thyroid hormone receptor-β	Human	tiratricol	184	68.8%	No
6266	Thyroid hormone receptor-β	Human	sobetirome	174	67.1%	No
6267	Thyroid hormone receptor-β	Human	KB-141	181	71.4%	No
6268	Thyroid hormone receptor-β	Human	T₄	188	66.5%	Yes
6269	Thyroid hormone receptor-β	Human	triiodothyronine	184	72.6%	Yes
6273	Retinoic acid receptor-α	Human	BMS614	208	88.1%	No
6285	Retinoic acid receptor-β	Human	TTNPB	212	79.0%	No
6287	Retinoic acid receptor-β	Human	tretinoin	200	74.5%	Yes
6288	Retinoic acid receptor-γ	Human	tretinoin	200	74.5%	Yes
6292	Retinoic acid receptor-γ	Human	BMS270394	104	41.9%	No
6299	Peroxisome proliferator-activated receptor-α	Human	GW409544	218	75.3%	No
6309	Peroxisome proliferator-activated receptor-α	Human	pirinixic acid	189	68.6%	No
6325	Peroxisome proliferator-activated receptor-β/δ	Human	GW2433	193	70.8%	No
6326	Peroxisome proliferator-activated receptor-β/δ	Human	GW0742X	192	69.5%	No
6332	Peroxisome proliferator-activated receptor-β/δ	Human	L-165041	210	78.3%	No
6338	Peroxisome proliferator-activated receptor-γ	Human	GW0072	106	38.9%	No
6339	Peroxisome proliferator-activated receptor-γ	Human	ragaglitazar	193	69.6%	No
6344	Peroxisome proliferator-activated receptor-γ	Human	nTzDpa	84	30.3%	No
6357	Peroxisome proliferator-activated receptor-γ	Human	rosiglitazone	193	45.8%	Yes
6359	Peroxisome proliferator-activated receptor-γ	Human	netoglitazone	192	69.7%	No
6362	Peroxisome proliferator-activated receptor-γ	Human	farglitazar	192	67.3%	No
6364	Peroxisome proliferator-activated receptor-γ	Human	indomethacin	193	66.9%	Yes
6369	Peroxisome proliferator-activated receptor-γ	Human	GW409544	194	68.2%	No
6398	RAR-related orphan receptor-α	Human	cholesterol	75	27.4%	No
6399	RAR-related orphan receptor-α	Human	cholesterol sulphate	93	34.1%	No
6410	Farnesoid X receptor	Human	chenodeoxycholic acid	183	78.1%	Yes
6414	Farnesoid X receptor	Human	GW4064	190	80.4%	No
6415	Farnesoid X receptor	Human	fexaramine	187	80.2%	No
6426	Liver X receptor-α	Human	L-783483	187	65.7%	No
6428	Liver X receptor-α	Human	GW3965	187	65.7%	No
6429	Liver X receptor-α	Human	T0901317	179	73.6%	No
6433	Liver X receptor-β	Human	24(S), 25-epoxycholesterol	219	87.2%	No
6435	Liver X receptor-β	Human	GW3965	190	74.7%	No
6436	Liver X receptor-β	Human	T0901317	182	70.4%	No
6440	Constitutive androstane receptor	Human	CITCO	166	67.1%	No
6443	Constitutive androstane receptor	Mouse	androstenol	83	32.0%	No
6446	Vitamin D receptor	Human	calcipotriol	204	77.2%	Yes
6447	Vitamin D receptor	Human	lexacalcitol	211	81.1%	No
6448	Vitamin D receptor	Human	seocalcitol	229	86.7%	No
6450	Vitamin D receptor	Human	1,25-dihydroxyvitamin D3	204	78.4%	Yes
6465	Pregnane X receptor	Human	SR12813	215	67.7%	No
6467	Pregnane X receptor	Human	hyperforin	212	66.8%	No
6485	Retinoid X receptor-α	Human	alitretinoin	165	68.9%	Yes
6486	Retinoid X receptor-α	Human	bexarotene	169	73.7%	Yes
6507	Estrogen receptor-α	Human	diethylstilbestrol	186	70.9%	Yes
6508	Estrogen receptor-α	Human	4-hydroxytamoxifen	193	76.5%	No
6509	Estrogen receptor-α	Human	17β-estradiol	173	66.7%	Yes
6510	Estrogen receptor-α	Human	estrone	184	73.2%	Yes
6512	Estrogen receptor-α	Human	raloxifene	189	73.2%	Yes
6513	Estrogen receptor-α	Human	estriol	182	69.9%	Yes
6517	Estrogen receptor-α	Human	4-hydroxytamoxifen	193	76.5%	No
6522	Estrogen receptor-β	Human	17β-estradiol	182	75.7%	Yes
6523	Estrogen receptor-β	Human	genistein	182	71.3%	No
6532	Estrogen receptor-β	Human	R,R-THC	179	65.7%	No
6548	Estrogen-related receptor-γ	Human	4-hydroxytamoxifen	167	72.2%	No
6559	Androgen receptor	Rat	dihydrotestosterone	192	73.5%	No
6569	Androgen receptor	Human	cyproterone acetate	191	76.3%	Yes
6570	Glucocorticoid receptor	Human	dexamethasone	187	72.4%	Yes
6573	Glucocorticoid receptor	Human	cortisol	185	72.2%	Yes
6578	Mineralocorticoid receptor	Human	deoxycorticosterone	188	73.0%	No
6579	Mineralocorticoid receptor	Human	progesterone	177	69.0%	Yes
6580	Mineralocorticoid receptor	Human	aldosterone	188	68.0%	No
6583	Mineralocorticoid receptor	Human	dexamethasone	191	75.7%	Yes
6588	Progesterone receptor	Human	progesterone	192	74.6%	Yes
6593	Progesterone receptor	Human	levonorgestrel	177	68.2%	Yes
6596	Progesterone receptor	Human	asoprisnil	195	74.6%	No
6597	RAR-related orphan receptor-γ	Human	25-hydroxycholesterol	194	77.8%	No
6603	OX₁ receptor	Human	suvorexant	402	72.5%	Yes
6604	OX₂ receptor	Human	suvorexant	371	66.2%	Yes
6612	CXCR4	Human	isothiourea-1t	412	82.4%	No
6614	CXCR4	Human	isothiourea-1t	412	82.4%	No
6997	squalene synthase	Human	zaragozic acid A	247	71.7%	No
6998	squalene synthase	Human	zaragozic acid A	250	72.6%	No
7089	farnesyl diphosphate synthase	Human	isopentenyl diphosphate	296	78.7%	No
7090	farnesyl diphosphate synthase	Human	zoledronic acid	155	43.4%	Yes
7091	farnesyl diphosphate synthase	Human	zoledronic acid	155	43.4%	Yes
7092	farnesyl diphosphate synthase	Human	risedronate	158	42.0%	Yes
7093	farnesyl diphosphate synthase	Human	risedronate	158	42.0%	Yes
7116	farnesyl diphosphate synthase	Human	diphosphoric acid	184	48.8%	No
7117	farnesyl diphosphate synthase	Human	diphosphoric acid	184	48.8%	No
7122	farnesyl diphosphate synthase	Human	alendronate	155	44.0%	Yes
7125	farnesyl diphosphate synthase	Human	minodronic acid	159	41.8%	No
7126	farnesyl diphosphate synthase	Human	zoledronic acid	155	43.4%	Yes
7127	farnesyl diphosphate synthase	Human	zoledronic acid	155	43.4%	Yes
7130	farnesyl diphosphate synthase	Human	risedronate	158	42.0%	Yes
7131	farnesyl diphosphate synthase	Human	risedronate	158	42.0%	Yes
7136	farnesyl diphosphate synthase	Human	risedronate	158	42.0%	Yes
7185	geranylgeranyl diphosphate synthase	Human	geranylgeranyl diphosphate	182	60.1%	No
7547	Retinoic acid receptor-α	Human	Ro 40-6055	171	63.9%	No
7986	Peroxisome proliferator-activated receptor-α	Human	GW6471	98	36.1%	No
8003	Peroxisome proliferator-activated receptor-γ	Human	GW9662	168	35.8%	No
8005	Peroxisome proliferator-activated receptor-γ	Human	diclofenac	55	19.4%	Yes
8010	Glucocorticoid receptor	Human	[³H]dexamethasone	187	72.4%	No
8029	Androgen receptor	Human	[³H]methyltrienolone	174	65.8%	No
9220	H₁ receptor	Human	[¹¹C]doxepin	329	72.6%	No
9251	nicotinic acetylcholine receptor α9 subunit	Human	[³H]methyllycaconitine	107	48.6%	No
9403	PAR1	Human	vorapaxar	330	68.0%	Yes
9421	LGR4	Human	R-spondin-1	187	36.9%	No
9464	Rev-Erb-β	Human	heme	187	97.4%	No
11406	GluK1	Rat	dysiherbaine	204	79.0%	No
11470	GluK3	Rat	kainate	129	49.6%	No
13002	SERT	Human	paroxetine	407	74.0%	Yes
13735	Leukotriene A₄ hydrolase	Human	bestatin	250	40.8%	No
13762	phosphodiesterase 4A	Human	Ro20-1724	214	60.3%	No
13765	phosphodiesterase 4B	Human	rolipram	213	53.5%	No
13768	phosphodiesterase 4D	Human	Ro20-1724	214	61.0%	No
13769	phosphodiesterase 4D	Human	rolipram	214	64.2%	No
13777	phosphodiesterase 5A	Human	sildenafil	247	75.9%	Yes
13827	Ecto-5'-Nucleotidase	Human	αβ-methyleneADP	469	88.0%	No
14314	Androgen receptor	Human	methyltrienolone	174	65.8%	No
14315	Androgen receptor	Human	hydroxyflutamide	192	76.4%	No
14316	Androgen receptor	Human	dihydrotestosterone	174	68.9%	No
76926	P2Y₁ receptor	Human	BMS compound 16 [PMID:23368907]	66	15.4%	No
77163	Interleukin-1 receptor, type I	Human	IL-1 receptor antagonist	295	92.2%	No
78362	FFA1 receptor	Human	fasiglifam	341	69.2%	No
78396	Neuronal NOS	Rat	N^ωpropyl-L-arginine	120	28.4%	No
78401	farnesyl diphosphate synthase	Human	risedronate	158	42.0%	Yes
78402	farnesyl diphosphate synthase	Human	alendronate	155	44.0%	Yes
78414	phosphodiesterase 4D	Human	RS-25344	214	55.9%	No
78427	plasminogen	Human	tranexamic acid	60	67.0%	Yes
78429	plasminogen	Human	6-aminocaproic acid	31	38.0%	Yes
78434	plasminogen activator, urokinase	Human	compound 4 [PMID: 18163548]	219	83.2%	No
78440	chymase 1	Human	JNJ-10311795	180	79.2%	No
78451	MMP13	Human	compound 1 [PMID: 17935984]	62	36.3%	No
78461	Angiotensin-converting enzyme	Human	lisinopril	362	61.3%	Yes
78463	Angiotensin-converting enzyme	Human	captopril	243	41.1%	Yes
78465	dipeptidyl peptidase 4	Human	sitagliptin	616	84.5%	Yes
78474	Angiotensin-converting enzyme	Human	enalaprilat	243	41.1%	Yes
78477	beta-secretase 1	Human	LY2886721	326	73.5%	No
78481	dipeptidyl peptidase 4	Human	vildagliptin	586	79.1%	Yes
78493	dipeptidyl peptidase 4	Human	alogliptin	587	79.2%	Yes
78498	coagulation factor II, thrombin	Human	melagatran	196	75.3%	No
78503	dipeptidyl peptidase 4	Human	linagliptin	536	72.9%	Yes
78505	coagulation factor X	Human	apixaban	134	56.8%	Yes
78507	dipeptidyl peptidase 4	Human	saxagliptin	586	80.4%	Yes
78508	renin	Human	aliskiren	213	62.4%	Yes
78509	coagulation factor X	Human	rivaroxaban	137	58.1%	Yes
78555	acetylcholinesterase (Cartwright blood group)	Human	donepezil	376	69.2%	Yes
78563	sphingosine kinase 1	Human	PF-543	147	39.4%	No
78567	Phenylethanolamine N-methyltransferase	Human	LY134046	235	83.0%	No
78568	Monoamine oxidase A	Human	clorgiline	192	36.2%	No
78578	mitogen-activated protein kinase 8	Human	SP600125	116	31.2%	No
78580	mitogen-activated protein kinase 10	Human	SP600125	137	37.4%	No
78583	mitogen-activated protein kinase 14	Human	SB203580	118	32.5%	No
78584	Rho associated coiled-coil containing protein kinase 1	Human	Y27632	287	68.9%	No
78591	phosphatidylinositol 4-kinase beta	Human	PIK-93	201	35.3%	No
78600	H-PGDS	Human	HQL-79	152	76.3%	No
78669	Leukotriene A₄ hydrolase	Human	DG-051	250	40.8%	No
78671	butyrylcholinesterase	Human	tacrine	357	67.3%	Yes
78675	acetylcholinesterase (Cartwright blood group)	Human	galantamine	362	66.6%	Yes
78680	PLA₂-G7	Human	darapladib	265	68.0%	No
78741	ABL proto-oncogene 1, non-receptor tyrosine kinase	Human	imatinib	135	49.1%	Yes
78743	epidermal growth factor receptor	Human	gefitinib	138	41.6%	Yes
78746	ABL proto-oncogene 1, non-receptor tyrosine kinase	Human	dasatinib	133	47.7%	Yes
78747	ABL proto-oncogene 1, non-receptor tyrosine kinase	Human	nilotinib	135	48.4%	Yes
78753	MET proto-oncogene, receptor tyrosine kinase	Human	crizotinib	147	47.7%	Yes
78759	kinase insert domain receptor	Human	axitinib	150	47.2%	Yes
78765	ABL proto-oncogene 1, non-receptor tyrosine kinase	Human	bosutinib	135	46.7%	Yes
78769	lanosterol synthase	Human	Ro 48-8071	607	82.8%	No
78800	Peroxisome proliferator-activated receptor-γ	Human	MRL20	186	67.8%	No
78807	CYP17A1	Human	abiraterone	370	74.7%	Yes
78858	carbonic anhydrase 1	Human	acetazolamide	119	45.4%	Yes
78861	carbonic anhydrase 1	Human	methazolamide	119	45.4%	Yes
78867	carbonic anhydrase 14	Human	acetazolamide	121	43.0%	Yes
78875	dihydroorotate dehydrogenase (quinone)	Human	teriflunomide	322	87.5%	Yes
78882	FK506 binding protein 1A	Human	tacrolimus	74	68.2%	Yes
78885	histone deacetylase 2	Human	vorinostat	275	74.3%	Yes
78890	histone deacetylase 8	Human	vorinostat	207	54.6%	Yes
78932	interleukin 1 beta	Human	canakinumab	111	69.6%	Yes
78934	glutathione-disulfide reductase	Human	oxiglutatione	447	96.7%	Yes
78981	Mineralocorticoid receptor	Human	spironolactone	191	74.2%	Yes
78983	Progesterone receptor	Human	progesterone	195	75.8%	Yes
78985	beta-secretase 1	Human	LY2811376	220	49.5%	No
78987	beta-secretase 1	Human	AZ-4217	313	75.9%	No
78993	beta-secretase 1	Human	oxazine 89	324	79.0%	No
79000	beta-secretase 1	Human	compound 2 [PMID: 22911925]	319	77.4%	No
79003	Retinoic acid receptor-α	Human	tretinoin	171	63.2%	Yes
79006	Retinoic acid receptor-β	Human	tretinoin	200	74.5%	Yes
79008	Retinoic acid receptor-γ	Human	tretinoin	200	74.5%	Yes
79022	anaplastic lymphoma receptor tyrosine kinase	Human	crizotinib	123	37.3%	Yes
79023	MET proto-oncogene, receptor tyrosine kinase	Human	crizotinib	147	47.7%	Yes
79043	B-Raf proto-oncogene, serine/threonine kinase	Human	dabrafenib	131	46.1%	Yes
79050	MET proto-oncogene, receptor tyrosine kinase	Human	foretinib	163	53.6%	No
79159	histone deacetylase 6	Human	trichostatin A	282	37.7%	No
79163	histone deacetylase 8	Human	trichostatin A	274	70.4%	No
79182	peptidylprolyl isomerase A	Human	cyclosporin A	31	18.3%	Yes
79183	carbonic anhydrase 12	Human	acetazolamide	120	45.2%	Yes
79189	carbonic anhydrase 1	Human	topiramate	137	52.3%	Yes
79197	carbonic anhydrase 7	Human	acetazolamide	118	43.5%	Yes
79201	carbonic anhydrase 7	Human	ethoxzolamide	116	40.9%	Yes
79214	phosphodiesterase 4B	Human	roflumilast	212	53.3%	Yes
79264	Estrogen receptor-α	Human	bazedoxifene	190	77.8%	Yes
79330	euchromatic histone lysine methyltransferase 1	Human	BIX-01294	85	32.2%	No
79332	euchromatic histone lysine methyltransferase 2	Human	UNC0638	95	33.2%	No
79333	euchromatic histone lysine methyltransferase 2	Human	UNC0638	92	32.2%	No
79339	DOT1 like histone lysine methyltransferase	Human	bromo-deaza-SAH	113	26.6%	No
79340	DOT1 like histone lysine methyltransferase	Human	pinometostat	81	18.8%	No
79341	DOT1 like histone lysine methyltransferase	Human	EPZ004777	166	46.9%	No
79342	DOT1 like histone lysine methyltransferase	Human	SGC0946	255	61.5%	No
79343	SET and MYND domain containing 2	Human	AZ505	154	35.3%	No
79346	PHD finger protein 8	Human	daminozide	131	34.8%	No
79359	protein arginine methyltransferase 3	Human	compound 1 [PMID: 22795084]	223	65.3%	No
79363	cyclin dependent kinase 2	Human	dinaciclib	125	41.6%	No
79368	cyclin dependent kinase 6	Human	palbociclib	145	46.8%	Yes
79385	SERT	Human	escitalopram	453	82.3%	Yes
79391	CYP19A1	Human	exemestane	363	72.0%	Yes
79412	COX-2	Human	meclofenamic acid	184	33.2%	Yes
79436	farnesyl diphosphate synthase	Human	pamidronic acid	158	41.9%	Yes
79448	phosphodiesterase 5A	Human	tadalafil	53	14.3%	Yes
79463	phosphodiesterase 5A	Human	vardenafil	247	75.9%	Yes
79481	Peroxisome proliferator-activated receptor-γ	Human	rosiglitazone	192	70.5%	Yes
79499	COX-2	Human	mefenamic acid	182	32.8%	Yes
79503	anaplastic lymphoma receptor tyrosine kinase	Human	ceritinib	135	36.5%	Yes
79510	farnesyl diphosphate synthase	Human	ibandronic acid	159	45.1%	Yes
79522	dihydrofolate reductase	Human	methotrexate	130	69.4%	Yes
79525	maltase-glucoamylase	Human	miglitol	606	69.1%	Yes
79526	epidermal growth factor receptor	Human	erlotinib	138	41.1%	Yes
79537	L-Phenylalanine hydroxylase	Human	sapropterin	86	26.2%	Yes
79548	epidermal growth factor receptor	Human	afatinib	207	62.4%	Yes
79553	B-Raf proto-oncogene, serine/threonine kinase	Human	vemurafenib	134	47.3%	Yes
79619	thymidylate synthetase	Mouse	raltitrexed	233	75.6%	Yes
79620	thymidylate synthetase	Human	raltitrexed	179	61.4%	Yes
79677	kinase insert domain receptor	Human	nintedanib	151	48.2%	Yes
79680	kinase insert domain receptor	Human	tivozanib	158	44.5%	No
79688	spleen associated tyrosine kinase	Human	tamatinib	125	42.6%	No
79689	kinase insert domain receptor	Human	lenvatinib	157	50.5%	Yes
79711	aldo-keto reductase family 1 member B	Human	tolrestat	284	89.6%	Yes
79767	Progesterone receptor	Human	ulipristal acetate	177	68.2%	Yes
79768	Progesterone receptor	Human	ulipristal acetate	177	68.2%	Yes
79786	anaplastic lymphoma receptor tyrosine kinase	Human	loratinib	149	45.3%	No
79896	CREB binding protein	Human	ischemin	64	52.1%	No
79898	bromodomain containing 4	Human	MS436	88	68.5%	No
79900	bromodomain containing 4	Human	(+)-JQ1	97	75.6%	No
79901	bromodomain containing 4	Human	MS417	97	75.6%	No
79904	bromodomain containing 4	Human	I-BET-762	97	75.6%	No
79905	bromodomain containing 2	Human	I-BET-762	68	58.8%	No
79907	bromodomain containing 2	Human	GW841819X	66	42.5%	No
79909	bromodomain containing 4	Human	GW841819X	69	53.5%	No
79910	bromodomain containing 4	Human	BzT-7	69	53.5%	No
79912	bromodomain containing 4	Human	compound 4d [PMID: 21851057]	69	53.5%	No
79914	bromodomain containing 2	Human	I-BET151	66	42.2%	No
79916	bromodomain containing 4	Human	I-BET151	69	53.5%	No
79917	poly(ADP-ribose) polymerase 1	Human	olaparib	127	46.5%	Yes
79918	poly(ADP-ribose) polymerase 2	Human	olaparib	139	37.5%	Yes
79925	bromodomain containing 4	Human	PFI-1	69	53.5%	No
79926	bromodomain containing 4	Human	BI-2536	60	46.5%	No
79928	polo like kinase 1	Human	BI-2536	127	42.9%	No
79935	bromodomain containing 4	Human	XD14	84	65.4%	No
79936	bromodomain containing 4	Human	XD1	65	50.8%	No
79939	bromodomain containing 4	Human	isoxazole azepine compound 3	97	75.0%	No
79940	bromodomain containing 4	Human	compound 15 (Hay et al., 2013)	69	53.5%	No
79941	CREB binding protein	Human	SGC-CBP30	69	57.1%	No
79942	E1A binding protein p300	Human	SGC-CBP30	72	61.2%	No
79959	Estrogen receptor-α	Human	lasofoxifene	180	70.8%	No
80081	Progesterone receptor	Human	tanaproget	177	68.0%	No
80082	aldo-keto reductase family 1 member B	Human	sorbinil	279	88.0%	No
80083	aldo-keto reductase family 1 member B	Human	lidorestat	290	90.6%	No
80084	aldo-keto reductase family 1 member B	Human	zopolrestat	291	91.8%	No
80085	aldo-keto reductase family 1 member B	Human	zenarestat	290	91.5%	No
80088	epidermal growth factor receptor	Human	AEE788	138	41.8%	No
80146	mitogen-activated protein kinase 14	Human	AZD6703	139	37.9%	No
80157	mitogen-activated protein kinase kinase 1	Human	selumetinib	138	40.2%	No
80200	AKT serine/threonine kinase 1	Human	AZD5363	281	82.6%	No
80208	checkpoint kinase 1	Human	AZD7762	167	60.6%	No
80251	SRC proto-oncogene, non-receptor tyrosine kinase	Human	saracatinib	132	24.5%	No
80263	poly(ADP-ribose) polymerase 1	Human	rucaparib	145	40.9%	No
80268	β₂-adrenoceptor	Human	carazolol	332	66.2%	Yes
80282	anaplastic lymphoma receptor tyrosine kinase	Human	brigatinib	149	46.4%	No
80285	anaplastic lymphoma receptor tyrosine kinase	Human	brigatinib	149	46.4%	No
80292	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	Human	CH5132799	161	16.6%	No
80328	Pim-1 proto-oncogene, serine/threonine kinase	Human	Akt inhibitor X	138	47.6%	No
80334	cyclin dependent kinase 5	Human	aloisine A	103	34.9%	No
80337	glycogen synthase kinase 3 beta	Human	alsterpaullone	116	27.1%	No
80348	aurora kinase A	Human	aurora kinase inhibitor III	230	84.2%	No
80356	Pim-1 proto-oncogene, serine/threonine kinase	Human	ruboxistaurin	143	45.5%	No
80420	glycogen synthase kinase 3 beta	Human	GSK-3beta inhibitor VIII	127	30.4%	No
80427	protein kinase, cAMP-dependent, catalytic, alpha subunit	Human	H-89	278	79.6%	No
80430	glycogen synthase kinase 3 beta	Human	indirubin-3'-monoxime	127	29.7%	No
80436	Janus kinase 2	Human	JAK inhibitor I	140	47.8%	No
80437	Janus kinase 3	Human	JAK inhibitor I	129	39.1%	No
80438	tyrosine kinase 2	Human	JAK inhibitor I	128	42.1%	No
80504	coagulation factor X	Human	eribaxaban	136	57.7%	No
80519	epidermal growth factor receptor	Human	PD 174265	115	34.1%	No
80524	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	Human	PI 3-Kg inhibitor	155	15.9%	No
80528	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	Human	PI 3-Kg inhibitor II	155	15.9%	No
80549	FK506 binding protein 1A	Human	sirolimus	95	87.9%	Yes
80557	cyclin dependent kinase 2	Human	seliciclib	125	41.6%	No
80561	mitogen-activated protein kinase 14	Human	SB220025	118	30.9%	No
80574	cyclin dependent kinase 2	Human	SU9516	115	38.3%	No
80583	transforming growth factor beta receptor 1	Human	TGF-beta RI kinase inhibitor	141	42.9%	No
80594	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Human	wortmannin	701	64.2%	No
80614	mitogen-activated protein kinase 1	Human	ERK inhibitor II	116	31.3%	No
80623	bromodomain containing 2	Human	ME bromodomain inhibitor	66	57.0%	No
80624	bromodomain containing 2	Human	ET bromodomain inhibitor	66	57.0%	No
80625	bromodomain containing 4	Human	compound 1 [PMID: 25408830]	60	38.6%	No
80630	bromodomain and PHD finger containing 1	Human	compound 3 [PMID: 25408830]	76	63.6%	No
80639	mitogen-activated protein kinase 14	Human	talmapimod	133	36.5%	No
80641	mitogen-activated protein kinase 14	Human	PH-797804	82	22.5%	No
80658	MMP12	Human	RXP470.1	95	59.1%	No
80672	mitogen-activated protein kinase 14	Human	BMS-582949	134	36.3%	No
80692	Androgen receptor	Human	andarine	196	78.3%	No
80705	Neutral endopeptidase	Human	sacubitrilat	617	88.3%	No
80713	Angiotensin-converting enzyme 2	Human	MLN-4760	243	39.3%	No
80716	cyclin dependent kinase 2	Human	roniciclib	135	45.0%	No
80719	fibroblast growth factor receptor 1	Human	BGJ-398	150	39.0%	No
80724	Angiotensin-converting enzyme	Human	RXP-407	243	38.5%	No
80753	AKT serine/threonine kinase 1	Human	ipatasertib	282	82.6%	No
80759	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	Human	apitolisib	163	16.8%	No
80764	spleen associated tyrosine kinase	Human	entospletinib	136	46.4%	No
80775	ABL proto-oncogene 1, non-receptor tyrosine kinase	Human	bafetinib	135	45.7%	No
80784	3-phosphoinositide dependent protein kinase 1	Human	7-hydroxystaurosporine	135	43.4%	No
80797	Janus kinase 2	Human	filgotinib	140	47.8%	No
80802	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	Human	PFI-3	63	51.2%	No
80808	polo like kinase 1	Human	NMS-P937	138	44.1%	No
80833	mitogen-activated protein kinase kinase 1	Human	PD 0325901	141	41.1%	No
80835	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Human	PF-04691502	164	17.2%	No
80836	aurora kinase A	Human	danusertib	116	41.1%	No
80839	cyclin dependent kinase 2	Human	milciclib	128	41.1%	No
80845	mitogen-activated protein kinase kinase 1	Human	refametinib	137	39.9%	No
80860	protein kinase C alpha	Human	sotrastaurin	137	38.0%	No
80866	polo like kinase 1	Human	volasertib	127	37.6%	No
80880	Insulin-like growth factor I receptor	Human	BMS-754807	154	48.6%	No
80886	Janus kinase 2	Human	BMS-911543	140	46.5%	No
80974	mechanistic target of rapamycin	Human	PI-103	173	14.7%	No
80998	HCK proto-oncogene, Src family tyrosine kinase	Human	PP121	132	28.9%	No
81001	glycogen synthase kinase 3 beta	Human	CHIR-99021	127	29.8%	No
81018	farnesyltransferase, CAAX box, beta	Human	tipifarnib	267	60.9%	No
81034	ribosomal protein S6 kinase B1	Human	PF-4708671	281	81.2%	No
81041	ribosomal protein S6 kinase A3	Human	BI-D1870	263	79.4%	No
81051	mitogen-activated protein kinase 14	Human	VX-745	138	37.8%	No
81064	MET proto-oncogene, receptor tyrosine kinase	Human	SGX-523	147	46.1%	No
81065	B-Raf proto-oncogene, serine/threonine kinase	Human	GDC-0879	121	36.5%	No
81068	mitogen-activated protein kinase-activated protein kinase 2	Human	PF-3644022	138	41.9%	No
81069	mitogen-activated protein kinase-activated protein kinase 2	Human	PF-3644022	138	41.9%	No
81080	casein kinase 1 delta	Human	PF-4800567	133	44.6%	No
81086	CDC like kinase 1	Human	KH-CB19	158	46.6%	No
81087	CDC like kinase 3	Human	KH-CB19	159	41.5%	No
81089	mitogen-activated protein kinase 1	Human	SCH772984	137	37.7%	No
81090	mitogen-activated protein kinase 1	Human	SCH772984	137	37.7%	No
81091	mitogen-activated protein kinase 7	Human	XMD8-92	129	37.0%	No
81100	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	Human	pictilisib	163	16.9%	No
81104	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	Human	AZD6482	163	16.8%	No
81109	aurora kinase A	Human	MK-5108	118	43.5%	No
81113	TANK binding kinase 1	Human	MRT67307	141	21.2%	No
81115	polo like kinase 1	Human	BI-2536	127	42.9%	No
81116	polo like kinase 2	Human	BI-2536	236	76.3%	No
81122	Bruton tyrosine kinase	Human	CGI1746	139	50.9%	No
81137	mitogen-activated protein kinase kinase kinase 7	Human	NG-25	100	31.5%	No
81146	mitogen-activated protein kinase kinase kinase 7	Human	5Z-7-oxozeaenol	134	42.2%	No
81169	kinase insert domain receptor	Human	axitinib	150	47.2%	Yes
81173	B-Raf proto-oncogene, serine/threonine kinase	Human	CHIR-265	133	47.0%	No
81175	kinase insert domain receptor	Human	sorafenib	158	50.8%	Yes
81179	epidermal growth factor receptor	Human	erlotinib	138	41.1%	Yes
81180	epidermal growth factor receptor	Human	gefitinib	138	41.6%	Yes
81202	MET proto-oncogene, receptor tyrosine kinase	Human	foretinib	163	53.6%	No
81205	MET proto-oncogene, receptor tyrosine kinase	Human	SGX-523	147	46.1%	No
81210	aurora kinase A	Human	MLN-8054	137	50.0%	No
81211	aurora kinase A	Human	MLN-8054	137	50.0%	No
81212	aurora kinase A	Human	tozasertib	136	50.6%	No
81213	aurora kinase B	Human	tozasertib	125	42.5%	No
81214	aurora kinase A	Human	tozasertib	136	50.6%	No
81218	B-Raf proto-oncogene, serine/threonine kinase	Human	PLX-4720	133	47.1%	No
81219	B-Raf proto-oncogene, serine/threonine kinase	Human	PLX-4720	133	47.1%	No
81225	KIT proto-oncogene receptor tyrosine kinase	Human	sunitinib	159	47.0%	Yes
81286	KIT proto-oncogene receptor tyrosine kinase	Human	sunitinib	159	47.0%	Yes
81287	kinase insert domain receptor	Human	sunitinib	158	44.5%	Yes
81294	spleen associated tyrosine kinase	Human	tamatinib	125	42.6%	No
81305	kinase insert domain receptor	Human	sorafenib	158	50.8%	Yes
81311	B-Raf proto-oncogene, serine/threonine kinase	Human	sorafenib	133	47.8%	Yes
81345	Rho associated coiled-coil containing protein kinase 1	Human	fasudil	287	68.9%	Yes
81347	Rho associated coiled-coil containing protein kinase 1	Human	fasudil	287	68.9%	Yes
81366	cell division cycle 7	Human	XL413	127	34.9%	No
81398	SRC proto-oncogene, non-receptor tyrosine kinase	Human	bosutinib	132	45.8%	Yes
81423	casein kinase 2, alpha 1 polypeptide subunit	Human	CX-4945	131	38.6%	No
81435	casein kinase 2, alpha 1 polypeptide subunit	Human	compound 1a [PMID: 24900749]	125	37.2%	No
81443	serine/threonine kinase 10	Human	bosutinib	269	90.8%	Yes
81444	mitogen-activated protein kinase kinase kinase 5	Human	compound 10 [PMID: 23147077]	128	47.2%	No
81449	AKT serine/threonine kinase 2	Human	GSK690693	260	77.8%	No
81491	EPH receptor A3	Human	compound 66 [PMID: 19788238]	130	35.7%	No
81500	beta adrenergic receptor kinase 1	Human	balanol	141	20.3%	No
81546	mitogen-activated protein kinase kinase 6	Human	staurosporine	128	43.8%	No
81547	death associated protein kinase 1	Human	staurosporine	143	51.1%	No
81554	Rho associated coiled-coil containing protein kinase 1	Human	RKI-1447	284	69.0%	No
81576	Pim-1 proto-oncogene, serine/threonine kinase	Human	compound 20 [PMID: 22136433]	142	44.9%	No
81577	Pim-3 proto-oncogene, serine/threonine kinase	Human	compound 20 [PMID: 22136433]	142	44.9%	No
81635	IL2 inducible T-cell kinase	Human	compound 7 [PMID: 22464456]	131	48.9%	No
81639	mitogen-activated protein kinase kinase kinase 14	Human	compound 31 [PMID: 23374866]	128	35.7%	No
81653	serine/threonine kinase 24	Human	bosutinib	122	39.2%	Yes
81673	mitogen-activated protein kinase-activated protein kinase 2	Human	compound 16 [PMID: 17480064]	138	41.0%	No
81707	Rho associated coiled-coil containing protein kinase 1	Human	Y27632	287	68.9%	No
81767	mechanistic target of rapamycin	Human	PP-242	174	14.7%	No
81808	transforming growth factor beta receptor 1	Human	SB-431542	141	45.3%	No
81842	lysine demethylase 6B	Human	IOX1	92	27.4%	No
81844	WD repeat domain 5	Human	OICR-9429	257	82.1%	No
81847	bromodomain adjacent to zinc finger domain 2B	Human	GSK2801	63	53.0%	No
81848	SET domain containing lysine methyltransferase 7	Human	(R)-PFI-2	96	36.0%	No
81854	SET and MYND domain containing 2	Human	LLY-507	119	26.8%	No
81894	amyloid P component, serum	Human	CPHPC	91	44.1%	No
81910	purine nucleoside phosphorylase	Human	forodesine	225	77.5%	No
81911	poly(ADP-ribose) polymerase 1	Human	niraparib	145	40.2%	No
81924	protein arginine methyltransferase 5	Human	EPZ015666	272	42.0%	No
81928	Monoamine oxidase B	Human	safinamide	334	64.0%	Yes
81929	Monoamine oxidase B	Human	safinamide	334	64.0%	Yes
81930	squalene synthase	Human	compound 15a [PMID: 22464687]	273	80.0%	No
81931	MET proto-oncogene, receptor tyrosine kinase	Human	AM7	128	41.0%	No
81932	leucine rich repeat kinase 2	Human	PF-06454589	122	41.9%	No
81938	dipeptidyl peptidase 4	Human	compound 1 (Xiao et al. 2014)	616	81.8%	No
81939	bromodomain adjacent to zinc finger domain 2B	Human	compound 1 [PMID: 25719566]	64	53.8%	No
81940	bromodomain containing 4	Human	compound 7d [PMID: 25703523]	60	46.5%	No
81941	bromodomain adjacent to zinc finger domain 2B	Human	compound 7 [PMID: 25719566]	58	48.7%	No
81944	Janus kinase 2	Human	decernotinib	139	46.9%	No
81950	CYP11B2	Human	fadrozole	373	77.0%	Yes
81953	poly(ADP-ribose) polymerase 1	Human	talazoparib	230	61.9%	No
81954	poly(ADP-ribose) polymerase 2	Human	talazoparib	231	62.5%	No
81962	BCL2, apoptosis regulator	Human	navitoclax	103	61.4%	No
82033	glutaminyl-peptide cyclotransferase	Human	PBD150	216	65.3%	No
82041	bromodomain containing 4	Human	LY 294002	66	51.2%	No
82072	transthyretin	Human	tafamidis	104	81.1%	Yes
82102	bromodomain containing 9	Human	I-BRD9	68	63.2%	No
82125	A_2A receptor	Human	UK-432,097	360	73.6%	No
82200	poly (ADP-ribose) polymerase 3	Human	ME0328	228	63.6%	No
82209	B-Raf proto-oncogene, serine/threonine kinase	Human	AZ628	115	40.6%	No
82212	glycogen synthase kinase 3 beta	Human	AZD2858	118	25.2%	No
82339	protein arginine methyltransferase 3	Human	SGC707	223	65.3%	No
82362	bromodomain containing 9	Human	LP99	66	52.8%	No
82372	bromodomain and PHD finger containing 1	Human	PFI-4	80	68.1%	No
82388	M₁ receptor	Human	tiotropium	328	63.5%	Yes
82425	LPA₁ receptor	Human	ONO-3080573	332	72.1%	No
82426	LPA₁ receptor	Human	ONO-9780307	355	76.3%	No
82427	LPA₁ receptor	Human	ONO-9910539	355	76.3%	No
82443	insulin degrading enzyme	Human	NTE-1	408	41.2%	No
82444	insulin degrading enzyme	Human	NTE-2	409	41.3%	No
82445	insulin degrading enzyme	Human	quinoline 2	282	28.4%	No
82448	furin, paired basic amino acid cleaving enzyme	Human	MI-1148	216	44.6%	No
82454	fatty acid synthase	Human	GSK2194069	469	70.9%	No
82515	MMP13	Human	compound 15 [PMID: 22017539]	113	65.5%	No
82516	aldo-keto reductase family 1 member B	Human	AK198	284	89.6%	No
82517	CYP17A1	Human	galeterone	370	74.7%	No
82521	ATPase family, AAA domain containing 2	Human	compound 60 [PMID: 26155854]	59	44.6%	No
82602	ADAM17	Human	IK-862	102	38.7%	No
82636	beta-secretase 1	Human	compound 16 [PMID: 23412139]	326	82.3%	No
82660	CD38	Human	isatuximab	160	62.1%	No
82672	poly(ADP-ribose) polymerase 2	Human	compound 10b [PMID: 26222319]	146	39.9%	No
82673	poly(ADP-ribose) polymerase 1	Human	compound 10b [PMID: 26222319]	127	34.8%	No
82674	ATPase family, AAA domain containing 2	Human	compound 33 [PMID: 26230603]	71	53.8%	No
82686	bromodomain containing 4	Human	RVX 208	83	71.9%	No
82687	bromodomain containing 2	Human	RVX 208	83	71.9%	No
82690	Peroxisome proliferator-activated receptor-γ	Human	resveratrol	79	27.2%	No
82694	lysine demethylase 4A	Human	compound 6a [PMID: 18942826]	145	37.8%	No
82695	lysine demethylase 4E	Human	compound 6a [PMID: 18942826]	145	40.2%	No
82697	CYP2D6	Human	ajmalicine	374	77.9%	Yes
82710	CYP2A6	Human	compound 39a [PMID: 15634016]	374	78.4%	No
82796	retinol binding protein 4	Human	A1120	101	47.2%	No
82822	CYP3A4	Human	ritonavir	374	76.9%	Yes
82826	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	Human	compound 82 [PMID: 21332118]	155	16.0%	No
82830	mechanistic target of rapamycin	Human	compound 82 [PMID: 21332118]	155	16.0%	No
82842	mPGES1	Human	compound 30 [PMID: 15953724]	107	68.8%	No
82872	RTP Type G	Human	compound 1 [PMID: 21882820]	89	28.4%	No
82891	mechanistic target of rapamycin	Human	torin 2	172	14.6%	No
82905	MMP1	Human	CGS-27023A	61	35.7%	No
82936	fibroblast growth factor receptor 4	Human	BLU9931	119	39.3%	No
82972	NOP receptor	Human	SB 612111	203	47.6%	No
82981	fatty acid binding protein 4	Mouse	HTS01037	113	85.5%	No
83004	GluK2	Rat	kainate	179	68.2%	No
83037	DOT1 like histone lysine methyltransferase	Human	bromo-deaza-SAH	113	26.6%	No
83076	Rev-Erb-β	Human	cobalt protoporphyrin IX	192	96.0%	No
83084	Retinoic acid receptor-α	Human	Ro 40-6055	171	63.9%	No
83093	Peroxisome proliferator-activated receptor-γ	Human	bexarotene	169	73.7%	Yes
83094	Estrogen-related receptor-γ	Human	GSK5182	173	76.1%	No
83095	Estrogen-related receptor-γ	Human	4-hydroxytamoxifen	167	72.2%	No
83096	Estrogen receptor-α	Human	4-hydroxytamoxifen	193	76.5%	No
83118	mitogen-activated protein kinase kinase 1	Human	cobimetinib	148	48.8%	Yes
83121	MET proto-oncogene, receptor tyrosine kinase	Human	tepotinib	147	50.2%	No
83128	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	Human	AMG319	162	16.8%	No
83160	p21 (RAC1) activated kinase 1	Human	PF-3758309	263	87.3%	No
83169	p21 (RAC1) activated kinase 6	Human	PF-3758309	129	44.0%	No
83171	p21 (RAC1) activated kinase 1	Human	FRAX597	244	81.0%	No
83183	neurotrophic receptor tyrosine kinase 2	Human	GW-2580	126	41.8%	No
83194	B-Raf proto-oncogene, serine/threonine kinase	Human	LY3009120	124	40.1%	No
83214	bromodomain containing 9	Human	BI-9564	65	52.0%	No
83226	SET and MYND domain containing 2	Human	BAY-598	155	35.6%	No
83227	protein arginine methyltransferase 5	Human	GSK591	281	43.4%	No
83231	protein arginine methyltransferase 6	Human	MS023	269	71.3%	No
83232	protein arginine methyltransferase 6	Human	MS023	269	71.3%	No
83246	B-Raf proto-oncogene, serine/threonine kinase	Human	BGB-283	132	44.9%	No
83277	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	Human	omipalisib	161	16.6%	No
83291	lysine demethylase 5B	Human	GSK-J1	162	33.5%	No
83383	Arginase I	Human	compound 9 [PMID: 23472952]	177	56.1%	No
83384	Arginase II	Human	compound 9 [PMID: 23472952]	177	57.5%	No
83385	indoleamine 2,3-dioxygenase 1	Human	NLG919	136	33.5%	No
83479	peptidyl arginine deiminase 4	Human	o-F-amidine	299	44.4%	No
83481	Neutral endopeptidase	Human	compound 1a [PMID: 25692029]	612	87.8%	No
83483	Leukotriene A₄ hydrolase	Human	compound 1a [PMID: 25692029]	430	69.6%	No
83518	bromodomain containing 4	Human	CPI-0610	97	75.0%	No
83541	receptor interacting serine/threonine kinase 2	Human	GSK583	141	42.9%	No
83546	OX₁ receptor	Human	SB-674042	401	72.3%	No
83551	SERT	Human	escitalopram	407	74.0%	Yes
83552	SERT	Human	paroxetine	407	74.0%	Yes
83559	Neuronal NOS	Human	compound 14j [PMID: 27050842]	115	27.1%	No
83560	Neuronal NOS	Rat	compound 14j [PMID: 27050842]	115	27.0%	No
83605	ABL proto-oncogene 1, non-receptor tyrosine kinase	Human	rebastinib	135	48.4%	No
83611	epidermal growth factor receptor	Human	WZ4002	124	37.2%	No
83652	κ receptor	Human	JDTic	369	76.7%	No
83653	κ receptor	Human	JDTic	369	76.7%	No
83677	transmembrane protein 173	Human	2'3'-cGAMP	103	42.1%	No
83697	mitogen-activated protein kinase 1	Human	GDC-0994	137	38.6%	No
83711	A_2A receptor	Human	compound 4g [PMID: 22220592]	107	32.2%	No
83738	heat shock protein 90 alpha family class A member 1	Human	BIIB021	134	56.1%	No
83739	heat shock protein 90 alpha family class A member 1	Human	SNX0723	132	56.2%	No
83743	Bruton tyrosine kinase	Human	GDC-0834	145	53.3%	No
83753	TTK protein kinase	Human	MPS1-IN-1	133	42.2%	No
83879	mitogen-activated protein kinase 14	Human	TAK-715	142	39.0%	No
83925	dual specificity tyrosine phosphorylation regulated kinase 1A	Human	harmine	122	33.0%	No
83947	pyruvate dehydrogenase kinase 1	Human	AZD7545	137	33.4%	No
83954	Pim-1 proto-oncogene, serine/threonine kinase	Human	LGB321	143	43.4%	No
83964	casein kinase 1 delta	Human	PF-670462	126	42.2%	No
83976	mitogen-activated protein kinase 1	Human	VTX-11e	137	37.7%	No
83982	mitogen-activated protein kinase 10	Human	JNK inhibitor 9l	134	36.8%	No
83984	phosphatidylinositol 3-kinase catalytic subunit type 3	Human	PIK-III	128	20.3%	No
83989	protein tyrosine kinase 2	Human	PF-562271	143	51.4%	No
84009	spleen associated tyrosine kinase	Human	GSK143	136	48.7%	No
84035	TTK protein kinase	Human	MPI-0479605	135	42.9%	No
84036	TTK protein kinase	Human	AZ3146	124	39.4%	No
84037	TTK protein kinase	Human	NMS-P715	155	49.2%	No
84039	polo like kinase 1	Human	Ro3280	126	34.9%	No
84040	polo like kinase 1	Human	Ro3280	126	34.9%	No
84043	LCK proto-oncogene, Src family tyrosine kinase	Human	PP2	132	47.1%	No
84085	TTK protein kinase	Human	BAY1161909	151	48.1%	No
84094	CCR2	Human	BMS-681	419	82.4%	No
84096	CCR2	Human	CCR2-RA-[R]	410	80.7%	No
84134	mitogen-activated protein kinase kinase kinase 7	Human	compound 12 [PMID: 27448772]	134	42.2%	No
84261	mixed lineage kinase domain like pseudokinase	Human	MLKL compound 1	141	49.5%	No
84262	mixed lineage kinase domain like pseudokinase	Human	MLKL compound 1	141	49.5%	No
84269	ATPase family, AAA domain containing 2	Human	GSK8814	65	49.2%	No
84270	ATPase family, AAA domain containing 2	Human	GSK8814	65	49.2%	No
84272	ATPase family, AAA domain containing 2	Human	GSK8814	65	49.2%	No
84275	bromodomain and PHD finger containing 1	Human	OF-1	76	64.7%	No
84279	embryonic ectoderm development	Human	A-395	336	90.1%	No
84326	receptor interacting serine/threonine kinase 1	Human	GSK2982772	132	43.2%	No
84335	PAR2	Human	AZ3451	136	21.8%	No
84336	PAR2	Human	AZ3451	136	21.8%	No
84366	glucagon receptor	Human	NNC0640	59	10.1%	No
84391	GLP-1 receptor	Human	Peptide 5 [PMID: 28562585]	354	83.6%	No
84392	GLP-1 receptor	Human	Peptide 5 [PMID: 28562585]	354	83.6%	No
84430	CB₁ receptor	Human	AM11542	120	27.2%	No
84439	phosphodiesterase 10A	Human	PF-2545920	206	53.9%	No
84445	PAR2	Human	AZ3451	136	21.8%	No
84447	PAR2	Human	AZ8838	349	56.2%	No
84448	PAR2	Human	AZ8838	349	56.2%	No
84449	PAR2	Human	AZ8838	349	56.2%	No
84482	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	Human	pictilisib	163	16.9%	No
84487	Bruton tyrosine kinase	Human	ibrutinib	133	47.3%	Yes
84537	ET_B receptor	Human	K-8794	337	72.4%	No
84539	Glucocorticoid receptor	Human	GSK866	191	73.9%	No
84541	beta-secretase 1	Human	AMG-8718	220	53.3%	No
84542	mitogen-activated protein kinase kinase kinase 7	Human	Takinib	134	43.3%	No
84577	interleukin 1 receptor associated kinase 4	Human	PF-06650833	138	42.8%	No
84619	Glucocorticoid receptor	Human	budesonide	190	67.5%	Yes
84743	receptor interacting serine/threonine kinase 1	Human	necrostatin-1s	96	32.3%	No
84753	glucagon receptor	Human	NNC1702	518	89.9%	No
84813	Pim-1 proto-oncogene, serine/threonine kinase	Human	PIM447	143	43.4%	No
84824	chymase 1	Human	compound 7f [PMID: 29191554]	179	78.8%	No
84827	PLA₂-G7	Human	darapladib	263	67.5%	No
84828	PLA₂-G7	Human	darapladib	263	67.5%	No
84829	PLA₂-G7	Human	(S)-23 [PMID: 27933945]	269	69.1%	No
84830	PLA₂-G7	Human	(S)-23 [PMID: 27933945]	269	69.1%	No
84891	beta-secretase 1	Human	RO5508887	325	79.2%	No
84900	heat shock protein 90 alpha family class A member 1	Human	alvespimycin	134	61.9%	No
84911	mitogen-activated protein kinase 10	Human	tanzisertib	137	29.3%	No
84917	MET proto-oncogene, receptor tyrosine kinase	Human	merestinib	140	43.8%	No
84918	MET proto-oncogene, receptor tyrosine kinase	Human	merestinib	140	43.8%	No
84961	Bruton tyrosine kinase	Human	BMS-986142	119	44.2%	No
84981	RAR-related orphan receptor-γ	Human	TAK-828F	103	47.2%	No
85059	spleen associated tyrosine kinase	Human	tamatinib	125	42.6%	No
85060	dipeptidyl peptidase 4	Human	teneligliptin	586	79.1%	Yes
85068	mitogen-activated protein kinase kinase 1	Human	CH4987655	142	45.9%	No
85069	mitogen-activated protein kinase kinase 1	Human	TAK-733	139	42.1%	No
85089	mitogen-activated protein kinase 14	Human	pamapimod	82	21.8%	No
85230	Retinoic acid receptor-γ	Human	trifarotene	200	43.8%	No
85248	mitogen-activated protein kinase 1	Human	compound 27 [PMID: 29775310]	138	37.3%	No
85267	mitogen-activated protein kinase kinase kinase 12	Human	GNE-3511	112	37.0%	No
85268	mitogen-activated protein kinase kinase kinase 12	Human	compound 11 [PMID: 26431428]	112	37.0%	No
85282	Janus kinase 2	Human	tofacitinib	140	47.8%	Yes
85283	Janus kinase 3	Human	tofacitinib	140	42.5%	Yes
85284	tyrosine kinase 2	Human	tofacitinib	139	43.5%	Yes
85286	Janus kinase 2	Human	PF-04965842	139	46.3%	No
85292	Janus kinase 2	Human	filgotinib	140	47.8%	No
85295	Janus kinase 2	Human	decernotinib	139	46.9%	No
85309	Janus kinase 2	Human	PF-06263276	143	47.7%	No
85312	Janus kinase 2	Human	JNJ-7706621	140	48.1%	No
85316	IL2 inducible T cell kinase	Human	BMS-509744	132	49.2%	No
85405	Plasmodium falciparum dihydroorotate dehydrogenase	Plasmodium falciparum	DSM421	335	83.3%	No
85410	Plasmodium falciparum dihydroorotate dehydrogenase	Plasmodium falciparum 3D7	DSM421	335	83.3%	No
85411	Plasmodium falciparum dihydroorotate dehydrogenase	Plasmodium falciparum 3D7	DSM421	335	83.3%	No
85569	cyclin dependent kinase 2	Human	RO3306	134	44.6%	No
85570	cyclin dependent kinase 2	Human	RO3306	134	44.6%	No
85576	cyclin dependent kinase 2	Human	SU9516	115	38.3%	No
85577	cyclin dependent kinase 2	Human	SU9516	115	38.3%	No
85589	aurora kinase A	Human	JNJ-7706621	137	49.8%	No
85793	hydroxysteroid 11-beta dehydrogenase 1	Human	BMS-823778	58	19.9%	No
85807	MAP kinase interacting serine/threonine kinase 2	Human	tomivosertib	137	43.0%	No
85855	Pim-1 proto-oncogene, serine/threonine kinase	Human	compound 28 [PMID: 30624936]	138	47.9%	No
85927	Plasmodium falciparum proline--tRNA ligase	Plasmodium falciparum 3D7	halofuginone	176	34.6%	No