Human mitogen-activated protein kinase kinase 1
with refametinib
GtoP Target: mitogen-activated protein kinase kinase 1
Structure
Sequence
melkdddfekiselgagnGgvvfkvshkpsglvmarKlihleikpairnqiireLqvlhecnspyiVgfygafysdgeisicmehmdggsldqvlkkagripeqilgkvsiavikgltylrekhkimhrDvkpsnilvnsrgeiklcDFgVSgqLidsmansfvgtrsymsperlqgthysvqsdiwsmglslvemavgrypipppdakelelmfgcqvegdaaetpprprtpgrplssygmdsrppmaifelldyivnepppklpsgvfslefqdfvnkcliknpaeradlkqlmvhafikrsdaeevdfagwlcstiglnqpstpthaagvlehhhhhh
PDB Details
| PDB code | 3E8N |
| HET ID | A1001 |
| HET name | VRA |
| Receptor Chain | A |
Other Details
| Target Type | Enzyme |
| Affinity | 7.7 |
| Affinity type | pIC50 |
? Sequence length |
137 |
? Proportion of original chain length |
39.9% |
? Internal contacts |
3666 |
? External contacts |
390 |
? Contact ratio |
9.4 |
Features
Residue Distances