Human mitogen-activated protein kinase kinase 1
with selumetinib
GtoP Target: mitogen-activated protein kinase kinase 1
Structure
Sequence
melkdddfekiselgagNgGvvfkvshkpsglvmarKlihleikpairnqiireLqvlhecnspyiVgfygafysdgeisIcMehmdggsldqvlkkagripeqilgkvsiavikgltylrekhkimhrdvkpsnilvnsrgeiklcDFGVSgqLidsmansfvgtrsymsperlqgthysvqsdiwsmglslvemavgrypipppdakelelmfgcqvegdaaetpprprtpgrplssygmdsrppmaifelldyivnepppklpsgvfslefqdfvnkcliknpaeradlkqlmvhafikrsdaeevdfagwlcstiglnqpstpthaagvlqhhhhhh
PDB Details
| PDB code | 4U7Z |
| HET ID | A502 |
| HET name | 3EW |
| Receptor Chain | A |
Other Details
| Target Type | Enzyme |
| Affinity | 7.9 |
| Affinity type | pIC50 |
? Sequence length |
138 |
? Proportion of original chain length |
40.2% |
? Internal contacts |
3629 |
? External contacts |
398 |
? Contact ratio |
9.118091 |
Features
Residue Distances