Human mitogen-activated protein kinase kinase 1
with cobimetinib
GtoP Target: mitogen-activated protein kinase kinase 1
Structure
Sequence
malgelkdddfekiselgagNggvvfkvshkpsglvmarKlihleikpairnqiireLqvlhecnspyiVgfygafysdgeisIcMehmdggsldqvlkkagripeqilgkvsiavikgltylrekhkimhrDvkpsNilvnsrgeiklcDFgVSgqLidemanefvGtrsymsperlqgthysvqsdiwsmglslvemavgryprppmaifelldyivnepppklpsavfslefqdfvnkcliknpaeradlkqlmvhafikrsdaeevdfagwlcstiglnqpstpthaageghhhhhh
PDB Details
| PDB code | 4AN2 |
| HET ID | A1382 |
| HET name | EUI |
| Receptor Chain | A |
Other Details
| Target Type | Enzyme |
| Affinity | 9.1 |
| Affinity type | pIC50 |
? Sequence length |
148 |
? Proportion of original chain length |
48.8% |
? Internal contacts |
3903 |
? External contacts |
355 |
? Contact ratio |
10.994367 |
Features
Residue Distances