synpharm
A database of ligand-responsive protein sequences...

cobimetinib

CAS Registry No. - 934660-93-2
ChEMBL Ligand - CHEMBL2146883
PubChem CID - 16222096
Wikipedia - Cobimetinib
PEP - cobimetinib
RCSB PDB Ligand - EUI
DrugCentral Ligand - 5046
Reactome Drug - R-ALL-9657527
Reactome Reaction - R-HSA-9657606
Structure
Molecular Details
Molecular mass (Da) 531.06305
Hydrogen bond acceptors 5
Hydrogen bond donors 3
Polar surface area (A2) 64.6
Lipinski rules broken 0
logP 4.653
Other Details
Ligand type Synthetic organic
Radiolabelled No
Approved Yes
Approval Source FDA (2015)
Responsive Sequences
mitogen-activated protein kinase kinase 1 (148 residues)