synpharm
A database of ligand-responsive protein sequences...

vorinostat

CAS Registry No. - 149647-78-9
ChEMBL Ligand - CHEMBL98
DrugBank Ligand - DB02546
PubChem CID - 5311
Wikipedia - Vorinostat
PEP - vorinostat
RCSB PDB Ligand - SHH
DrugCentral Ligand - 4124
Reactome Drug - R-ALL-9679755
Reactome Reaction - R-HSA-9679787
Structure
Molecular Details
Molecular mass (Da) 264.1474
Hydrogen bond acceptors 3
Hydrogen bond donors 3
Polar surface area (A2) 78.43
Lipinski rules broken 0
logP 2.829
Other Details
Ligand type Synthetic organic
Radiolabelled No
Approved Yes
Approval Source FDA (2006)
Responsive Sequences
histone deacetylase 2 (275 residues)
histone deacetylase 8 (207 residues)