synpharm
A database of ligand-responsive protein sequences...

dabrafenib

CAS Registry No. - 1195765-45-7
ChEMBL Ligand - CHEMBL2028663
DrugBank Ligand - DB08912
PubChem CID - 44462760
Wikipedia - Dabrafenib
PEP - dabrafenib
RCSB PDB Ligand - P06
DrugCentral Ligand - 4801
Reactome Drug - R-ALL-6802252
Reactome Reaction - R-HSA-6802938
Structure
Molecular Details
Molecular mass (Da) 519.1011
Hydrogen bond acceptors 7
Hydrogen bond donors 2
Polar surface area (A2) 147.48
Lipinski rules broken 0
logP 4.789
Other Details
Ligand type Synthetic organic
Radiolabelled No
Approved Yes
Approval Source FDA and EMA (2013)
Responsive Sequences
B-Raf proto-oncogene, serine/threonine kinase (131 residues)