synpharm
A database of ligand-responsive protein sequences...

vemurafenib

PEP - vemurafenib
RCSB PDB Ligand - 32
RCSB PDB Ligand - 032
CAS Registry No. - 918504-65-1
ChEBI - CHEBI:63637
ChEMBL Ligand - CHEMBL1229517
DrugBank Ligand - DB08881
PubChem CID - 42611257
Wikipedia - Vemurafenib
DrugCentral Ligand - 4185
Reactome Drug - R-ALL-6802253
Reactome Reaction - R-HSA-6802938
Structure
Molecular Details
Molecular mass (Da) 489.07254
Hydrogen bond acceptors 6
Hydrogen bond donors 2
Polar surface area (A2) 100.3
Lipinski rules broken 1
logP 5.035
Other Details
Ligand type Synthetic organic
Radiolabelled No
Approved Yes
Approval Source FDA (2011), EMA (2012)
Responsive Sequences
B-Raf proto-oncogene, serine/threonine kinase (134 residues)