synpharm
A database of ligand-responsive protein sequences...

afatinib

PEP - afatinib
RCSB PDB Ligand - 0WM
CAS Registry No. - 850140-72-6
ChEMBL Ligand - CHEMBL1173655
DrugBank Ligand - DB08916
PubChem CID - 10184653
Wikipedia - Afatinib
DrugCentral Ligand - 4318
Reactome Drug - R-ALL-1220577
Reactome Reaction - R-HSA-1225978
Reactome Reaction - R-HSA-9652264
Reactome Reaction - R-HSA-9665412
Reactome Reaction - R-HSA-9665121
Reactome Reaction - R-HSA-9665311
Reactome Reaction - R-HSA-9665702
Reactome Reaction - R-HSA-1220611
Structure
Molecular Details
Molecular mass (Da) 485.163
Hydrogen bond acceptors 7
Hydrogen bond donors 2
Polar surface area (A2) 88.61
Lipinski rules broken 0
logP 3.06
Other Details
Ligand type Synthetic organic
Radiolabelled No
Approved Yes
Approval Source EMA & FDA (2013)
Responsive Sequences
epidermal growth factor receptor (207 residues)