synpharm
A database of ligand-responsive protein sequences...

All Drug Responsive Sequences

All
Approved drugs
Short
Long
Human
Non-Human
Small proportional length

All drug-responsive elements which respond to a Guide to PHARMACOLOGY ligand ().

ID Target Species Ligand Length Proportional length
1190M2 receptorHuman[3H]QNB30364.7%No
1460A2A receptorHumanCGS 2168019559.7%No
1467A2A receptorHumanNECA19559.7%No
1469A2A receptorHuman[3H]CGS 2168019559.7%No
1470A2A receptorHuman[3H]NECA19559.7%No
1490A2A receptorHumanxanthine amine congener19458.7%No
1491A2A receptorHumanZM-24138525051.0%No
1494A2A receptorHuman[3H]XAC19458.7%No
1495A2A receptorHumancaffeine10732.2%Yes
1862β2-adrenoceptorHuman(-)-adrenaline17637.3%Yes
1873β2-adrenoceptorHumanICI 11855133267.6%No
1879β2-adrenoceptorHumanalprenolol33668.4%Yes
1888β2-adrenoceptorHumantimolol33568.2%Yes
2181CaS receptorHumanCa2+81.1%No
2310CCR5Human[3H]maraviroc29871.7%No
2313CCR5Humanmaraviroc29871.7%Yes
2478CRF2 receptorHumanurocortin 142487.8%No
2633D3 receptorHumaneticlopride32767.8%No
2814GABAB receptorHumanGABA22152.4%No
2816GABAB receptorHumanbaclofen28567.6%Yes
2817GABAB receptorHumanCGP 3534828667.9%No
2820GABAB receptorHumanCGP 4638128667.9%No
2821GABAB receptorHumanCGP 54626A28667.9%No
2826GABAB receptorHumanSCH 5091128567.6%No
2828GABAB receptorHumanphaclofen28567.6%No
2980H1 receptorHumandoxepin32972.6%Yes
3817δ receptorHumannaltrindole18143.5%No
3818δ receptorMousenaltrindole33572.5%No
3941μ receptorMouseβ-FNA33471.8%No
3979NOP receptorHumanSB 61211120347.6%No
4014P2Y1 receptorHumanMRS250031875.3%No
4077P2Y12 receptorHuman2MeSADP29462.9%No
4083P2Y12 receptorHuman[3H]2MeSADP29462.9%No
5496HCN1Mousecyclic AMP7233.8%No
5504HCN2Mousecyclic AMP7034.7%No
5505HCN2Mousecyclic GMP6532.0%No
6258Thyroid hormone receptor-αHumantriiodothyronine18068.1%Yes
6259Thyroid hormone receptor-αHumanT417566.2%Yes
6261Thyroid hormone receptor-αHumantiratricol18068.1%No
6262Thyroid hormone receptor-αHumansobetirome17666.0%No
6263Thyroid hormone receptor-αHumanKB-14118469.6%No
6265Thyroid hormone receptor-βHumantiratricol18468.8%No
6266Thyroid hormone receptor-βHumansobetirome17467.1%No
6267Thyroid hormone receptor-βHumanKB-14118171.4%No
6268Thyroid hormone receptor-βHumanT418866.5%Yes
6269Thyroid hormone receptor-βHumantriiodothyronine18472.6%Yes
6273Retinoic acid receptor-αHumanBMS61420888.1%No
6285Retinoic acid receptor-βHumanTTNPB21279.0%No
6287Retinoic acid receptor-βHumantretinoin20074.5%Yes
6288Retinoic acid receptor-γHumantretinoin20074.5%Yes
6292Retinoic acid receptor-γHumanBMS27039410441.9%No
6299Peroxisome proliferator-activated receptor-αHumanGW40954421875.3%No
6309Peroxisome proliferator-activated receptor-αHumanpirinixic acid18968.6%No
6325Peroxisome proliferator-activated receptor-β/δHumanGW243319370.8%No
6326Peroxisome proliferator-activated receptor-β/δHumanGW0742X19269.5%No
6332Peroxisome proliferator-activated receptor-β/δHumanL-16504121078.3%No
6338Peroxisome proliferator-activated receptor-γHumanGW007210638.9%No
6339Peroxisome proliferator-activated receptor-γHumanragaglitazar19369.6%No
6344Peroxisome proliferator-activated receptor-γHumannTzDpa8430.3%No
6357Peroxisome proliferator-activated receptor-γHumanrosiglitazone19345.8%Yes
6359Peroxisome proliferator-activated receptor-γHumannetoglitazone19269.7%No
6362Peroxisome proliferator-activated receptor-γHumanfarglitazar19267.3%No
6364Peroxisome proliferator-activated receptor-γHumanindomethacin19366.9%Yes
6369Peroxisome proliferator-activated receptor-γHumanGW40954419468.2%No
6398RAR-related orphan receptor-αHumancholesterol7527.4%No
6399RAR-related orphan receptor-αHumancholesterol sulphate9334.1%No
6410Farnesoid X receptorHumanchenodeoxycholic acid18378.1%Yes
6414Farnesoid X receptorHumanGW406419080.4%No
6415Farnesoid X receptorHumanfexaramine18780.2%No
6426Liver X receptor-αHumanL-78348318765.7%No
6428Liver X receptor-αHumanGW396518765.7%No
6429Liver X receptor-αHumanT090131717973.6%No
6433Liver X receptor-βHuman24(S), 25-epoxycholesterol21987.2%No
6435Liver X receptor-βHumanGW396519074.7%No
6436Liver X receptor-βHumanT090131718270.4%No
6440Constitutive androstane receptorHumanCITCO16667.1%No
6443Constitutive androstane receptorMouseandrostenol8332.0%No
6446Vitamin D receptorHumancalcipotriol20477.2%Yes
6447Vitamin D receptorHumanlexacalcitol21181.1%No
6448Vitamin D receptorHumanseocalcitol22986.7%No
6450Vitamin D receptorHuman1,25-dihydroxyvitamin D320478.4%Yes
6465Pregnane X receptorHumanSR1281321567.7%No
6467Pregnane X receptorHumanhyperforin21266.8%No
6485Retinoid X receptor-αHumanalitretinoin16568.9%Yes
6486Retinoid X receptor-αHumanbexarotene16973.7%Yes
6507Estrogen receptor-αHumandiethylstilbestrol18670.9%Yes
6508Estrogen receptor-αHuman4-hydroxytamoxifen19376.5%No
6509Estrogen receptor-αHuman17β-estradiol17366.7%Yes
6510Estrogen receptor-αHumanestrone18473.2%Yes
6512Estrogen receptor-αHumanraloxifene18973.2%Yes
6513Estrogen receptor-αHumanestriol18269.9%Yes
6517Estrogen receptor-αHuman4-hydroxytamoxifen19376.5%No
6522Estrogen receptor-βHuman17β-estradiol18275.7%Yes
6523Estrogen receptor-βHumangenistein18271.3%No
6532Estrogen receptor-βHumanR,R-THC17965.7%No
6548Estrogen-related receptor-γHuman4-hydroxytamoxifen16772.2%No
6559Androgen receptorRatdihydrotestosterone19273.5%No
6569Androgen receptorHumancyproterone acetate19176.3%Yes
6570Glucocorticoid receptorHumandexamethasone18772.4%Yes
6573Glucocorticoid receptorHumancortisol18572.2%Yes
6578Mineralocorticoid receptorHumandeoxycorticosterone18873.0%No
6579Mineralocorticoid receptorHumanprogesterone17769.0%Yes
6580Mineralocorticoid receptorHumanaldosterone18868.0%No
6583Mineralocorticoid receptorHumandexamethasone19175.7%Yes
6588Progesterone receptorHumanprogesterone19274.6%Yes
6593Progesterone receptorHumanlevonorgestrel17768.2%Yes
6596Progesterone receptorHumanasoprisnil19574.6%No
6597RAR-related orphan receptor-γHuman25-hydroxycholesterol19477.8%No
6603OX1 receptorHumansuvorexant40272.5%Yes
6604OX2 receptorHumansuvorexant37166.2%Yes
6612CXCR4Humanisothiourea-1t41282.4%No
6614CXCR4Humanisothiourea-1t41282.4%No
6997squalene synthase Humanzaragozic acid A24771.7%No
6998squalene synthase Humanzaragozic acid A25072.6%No
7089farnesyl diphosphate synthaseHumanisopentenyl diphosphate29678.7%No
7090farnesyl diphosphate synthaseHumanzoledronic acid15543.4%Yes
7092farnesyl diphosphate synthaseHumanrisedronate15842.0%Yes
7116farnesyl diphosphate synthaseHumandiphosphoric acid18448.8%No
7125farnesyl diphosphate synthaseHumanminodronic acid15941.8%No
7185geranylgeranyl diphosphate synthaseHumangeranylgeranyl diphosphate18260.1%No
7547Retinoic acid receptor-αHumanRo 40-605517163.9%No
7986Peroxisome proliferator-activated receptor-αHumanGW64719836.1%No
8003Peroxisome proliferator-activated receptor-γHumanGW966216835.8%No
8005Peroxisome proliferator-activated receptor-γHumandiclofenac5519.4%Yes
8010Glucocorticoid receptorHuman[3H]dexamethasone18772.4%No
8029Androgen receptorHuman[3H]methyltrienolone17465.8%No
9220H1 receptorHuman[11C]doxepin32972.6%No
9251nicotinic acetylcholine receptor α9 subunitHuman[3H]methyllycaconitine10748.6%No
9403PAR1Humanvorapaxar33068.0%Yes
9421LGR4HumanR-spondin-118736.9%No
9464Rev-Erb-βHumanheme18797.4%No
11406GluK1Ratdysiherbaine20479.0%No
11470GluK3Ratkainate12949.6%No
13002SERTHumanparoxetine40774.0%Yes
13735Leukotriene A4 hydrolaseHumanbestatin25040.8%No
13762phosphodiesterase 4AHumanRo20-172421460.3%No
13765phosphodiesterase 4BHumanrolipram21353.5%No
13768phosphodiesterase 4DHumanRo20-172421461.0%No
13769phosphodiesterase 4DHumanrolipram21464.2%No
13777phosphodiesterase 5AHumansildenafil24775.9%Yes
13827Ecto-5'-NucleotidaseHumanαβ-methyleneADP46988.0%No
14314Androgen receptorHumanmethyltrienolone17465.8%No
14315Androgen receptorHumanhydroxyflutamide19276.4%No
14316Androgen receptorHumandihydrotestosterone17468.9%No
76926P2Y1 receptorHumanBMS compound 16 [PMID:23368907]6615.4%No
77163Interleukin-1 receptor, type IHumanIL-1 receptor antagonist29592.2%No
78362FFA1 receptorHumanfasiglifam34169.2%No
78396Neuronal NOSRatNωpropyl-L-arginine12028.4%No
78402farnesyl diphosphate synthaseHumanalendronate15544.0%Yes
78414phosphodiesterase 4DHumanRS-2534421455.9%No
78427plasminogenHumantranexamic acid6067.0%Yes
78429plasminogenHuman6-aminocaproic acid3138.0%Yes
78434plasminogen activator, urokinaseHumancompound 4 [PMID: 18163548]21983.2%No
78440chymase 1HumanJNJ-1031179518079.2%No
78451MMP13Humancompound 1 [PMID: 17935984]6236.3%No
78461Angiotensin-converting enzymeHumanlisinopril36261.3%Yes
78463Angiotensin-converting enzymeHumancaptopril24341.1%Yes
78465dipeptidyl peptidase 4Humansitagliptin61684.5%Yes
78474Angiotensin-converting enzymeHumanenalaprilat24341.1%Yes
78477beta-secretase 1HumanLY288672132673.5%No
78481dipeptidyl peptidase 4Humanvildagliptin58679.1%Yes
78493dipeptidyl peptidase 4Humanalogliptin58779.2%Yes
78498coagulation factor II, thrombinHumanmelagatran19675.3%No
78503dipeptidyl peptidase 4Humanlinagliptin53672.9%Yes
78505coagulation factor XHumanapixaban13456.8%Yes
78507dipeptidyl peptidase 4Humansaxagliptin58680.4%Yes
78508reninHumanaliskiren21362.4%Yes
78509coagulation factor XHumanrivaroxaban13758.1%Yes
78555acetylcholinesterase (Cartwright blood group)Humandonepezil37669.2%Yes
78563sphingosine kinase 1HumanPF-54314739.4%No
78567Phenylethanolamine N-methyltransferaseHumanLY13404623583.0%No
78568Monoamine oxidase AHumanclorgiline19236.2%No
78578mitogen-activated protein kinase 8HumanSP60012511631.2%No
78580mitogen-activated protein kinase 10HumanSP60012513737.4%No
78583mitogen-activated protein kinase 14HumanSB20358011832.5%No
78584Rho associated coiled-coil containing protein kinase 1HumanY2763228768.9%No
78591phosphatidylinositol 4-kinase betaHumanPIK-9320135.3%No
78600H-PGDSHumanHQL-7915276.3%No
78669Leukotriene A4 hydrolaseHumanDG-05125040.8%No
78671butyrylcholinesteraseHumantacrine35767.3%Yes
78675acetylcholinesterase (Cartwright blood group)Humangalantamine36266.6%Yes
78680PLA2-G7Humandarapladib26568.0%No
78741ABL proto-oncogene 1, non-receptor tyrosine kinaseHumanimatinib13549.1%Yes
78743epidermal growth factor receptorHumangefitinib13841.6%Yes
78746ABL proto-oncogene 1, non-receptor tyrosine kinaseHumandasatinib13347.7%Yes
78747ABL proto-oncogene 1, non-receptor tyrosine kinaseHumannilotinib13548.4%Yes
78753MET proto-oncogene, receptor tyrosine kinaseHumancrizotinib14747.7%Yes
78759kinase insert domain receptorHumanaxitinib15047.2%Yes
78765ABL proto-oncogene 1, non-receptor tyrosine kinaseHumanbosutinib13546.7%Yes
78769lanosterol synthaseHumanRo 48-807160782.8%No
78800Peroxisome proliferator-activated receptor-γHumanMRL2018667.8%No
78807CYP17A1Humanabiraterone37074.7%Yes
78858carbonic anhydrase 1Humanacetazolamide11945.4%Yes
78861carbonic anhydrase 1Humanmethazolamide11945.4%Yes
78867carbonic anhydrase 14Humanacetazolamide12143.0%Yes
78875dihydroorotate dehydrogenase (quinone)Humanteriflunomide32287.5%Yes
78882FK506 binding protein 1AHumantacrolimus7468.2%Yes
78885histone deacetylase 2Humanvorinostat27574.3%Yes
78890histone deacetylase 8Humanvorinostat20754.6%Yes
78932interleukin 1 betaHumancanakinumab11169.6%Yes
78934glutathione-disulfide reductaseHumanoxiglutatione44796.7%Yes
78981Mineralocorticoid receptorHumanspironolactone19174.2%Yes
78983Progesterone receptorHumanprogesterone19575.8%Yes
78985beta-secretase 1HumanLY281137622049.5%No
78987beta-secretase 1HumanAZ-421731375.9%No
78993beta-secretase 1Humanoxazine 8932479.0%No
79000beta-secretase 1Humancompound 2 [PMID: 22911925]31977.4%No
79003Retinoic acid receptor-αHumantretinoin17163.2%Yes
79006Retinoic acid receptor-βHumantretinoin20074.5%Yes
79008Retinoic acid receptor-γHumantretinoin20074.5%Yes
79022anaplastic lymphoma receptor tyrosine kinaseHumancrizotinib12337.3%Yes
79023MET proto-oncogene, receptor tyrosine kinaseHumancrizotinib14747.7%Yes
79043B-Raf proto-oncogene, serine/threonine kinaseHumandabrafenib13146.1%Yes
79050MET proto-oncogene, receptor tyrosine kinaseHumanforetinib16353.6%No
79159histone deacetylase 6Humantrichostatin A28237.7%No
79163histone deacetylase 8Humantrichostatin A27470.4%No
79182peptidylprolyl isomerase AHumancyclosporin A3118.3%Yes
79183carbonic anhydrase 12Humanacetazolamide12045.2%Yes
79189carbonic anhydrase 1Humantopiramate13752.3%Yes
79197carbonic anhydrase 7Humanacetazolamide11843.5%Yes
79201carbonic anhydrase 7Humanethoxzolamide11640.9%Yes
79214phosphodiesterase 4BHumanroflumilast21253.3%Yes
79264Estrogen receptor-αHumanbazedoxifene19077.8%Yes
79330euchromatic histone lysine methyltransferase 1HumanBIX-012948532.2%No
79332euchromatic histone lysine methyltransferase 2HumanUNC06389533.2%No
79333euchromatic histone lysine methyltransferase 2HumanUNC06389232.2%No
79339DOT1 like histone lysine methyltransferaseHumanbromo-deaza-SAH11326.6%No
79340DOT1 like histone lysine methyltransferaseHumanpinometostat8118.8%No
79341DOT1 like histone lysine methyltransferaseHumanEPZ00477716646.9%No
79342DOT1 like histone lysine methyltransferaseHumanSGC094625561.5%No
79343SET and MYND domain containing 2HumanAZ50515435.3%No
79346PHD finger protein 8Humandaminozide13134.8%No
79359protein arginine methyltransferase 3Humancompound 1 [PMID: 22795084]22365.3%No
79363cyclin dependent kinase 2Humandinaciclib12541.6%No
79368cyclin dependent kinase 6Humanpalbociclib14546.8%Yes
79385SERTHumanescitalopram45382.3%Yes
79391CYP19A1Humanexemestane36372.0%Yes
79412COX-2 Humanmeclofenamic acid18433.2%Yes
79436farnesyl diphosphate synthaseHumanpamidronic acid15841.9%Yes
79448phosphodiesterase 5AHumantadalafil5314.3%Yes
79463phosphodiesterase 5AHumanvardenafil24775.9%Yes
79481Peroxisome proliferator-activated receptor-γHumanrosiglitazone19270.5%Yes
79499COX-2 Humanmefenamic acid18232.8%Yes
79503anaplastic lymphoma receptor tyrosine kinaseHumanceritinib13536.5%Yes
79510farnesyl diphosphate synthaseHumanibandronic acid15945.1%Yes
79522dihydrofolate reductaseHumanmethotrexate13069.4%Yes
79525maltase-glucoamylaseHumanmiglitol60669.1%Yes
79526epidermal growth factor receptorHumanerlotinib13841.1%Yes
79537L-Phenylalanine hydroxylase Humansapropterin8626.2%Yes
79548epidermal growth factor receptorHumanafatinib20762.4%Yes
79553B-Raf proto-oncogene, serine/threonine kinaseHumanvemurafenib13447.3%Yes
79619thymidylate synthetaseMouseraltitrexed23375.6%Yes
79620thymidylate synthetaseHumanraltitrexed17961.4%Yes
79677kinase insert domain receptorHumannintedanib15148.2%Yes
79680kinase insert domain receptorHumantivozanib15844.5%No
79688spleen associated tyrosine kinaseHumantamatinib12542.6%No
79689kinase insert domain receptorHumanlenvatinib15750.5%Yes
79711aldo-keto reductase family 1 member BHumantolrestat28489.6%Yes
79767Progesterone receptorHumanulipristal acetate17768.2%Yes
79768Progesterone receptorHumanulipristal acetate17768.2%Yes
79786anaplastic lymphoma receptor tyrosine kinaseHumanloratinib14945.3%No
79896CREB binding proteinHumanischemin6452.1%No
79898bromodomain containing 4HumanMS4368868.5%No
79900bromodomain containing 4Human(+)-JQ19775.6%No
79901bromodomain containing 4HumanMS4179775.6%No
79904bromodomain containing 4HumanI-BET-7629775.6%No
79905bromodomain containing 2HumanI-BET-7626858.8%No
79907bromodomain containing 2HumanGW841819X6642.5%No
79909bromodomain containing 4HumanGW841819X6953.5%No
79910bromodomain containing 4HumanBzT-76953.5%No
79912bromodomain containing 4Humancompound 4d [PMID: 21851057]6953.5%No
79914bromodomain containing 2HumanI-BET1516642.2%No
79916bromodomain containing 4HumanI-BET1516953.5%No
79917poly(ADP-ribose) polymerase 1Humanolaparib12746.5%Yes
79918poly(ADP-ribose) polymerase 2Humanolaparib13937.5%Yes
79925bromodomain containing 4HumanPFI-16953.5%No
79926bromodomain containing 4HumanBI-25366046.5%No
79928polo like kinase 1HumanBI-253612742.9%No
79935bromodomain containing 4HumanXD148465.4%No
79936bromodomain containing 4HumanXD16550.8%No
79939bromodomain containing 4Humanisoxazole azepine compound 39775.0%No
79940bromodomain containing 4Humancompound 15 (Hay et al., 2013)6953.5%No
79941CREB binding proteinHumanSGC-CBP306957.1%No
79942E1A binding protein p300HumanSGC-CBP307261.2%No
79959Estrogen receptor-αHumanlasofoxifene18070.8%No
80081Progesterone receptorHumantanaproget17768.0%No
80082aldo-keto reductase family 1 member BHumansorbinil27988.0%No
80083aldo-keto reductase family 1 member BHumanlidorestat29090.6%No
80084aldo-keto reductase family 1 member BHumanzopolrestat29191.8%No
80085aldo-keto reductase family 1 member BHumanzenarestat29091.5%No
80088epidermal growth factor receptorHumanAEE78813841.8%No
80146mitogen-activated protein kinase 14HumanAZD670313937.9%No
80157mitogen-activated protein kinase kinase 1Humanselumetinib13840.2%No
80200AKT serine/threonine kinase 1HumanAZD536328182.6%No
80208checkpoint kinase 1HumanAZD776216760.6%No
80251SRC proto-oncogene, non-receptor tyrosine kinaseHumansaracatinib13224.5%No
80263poly(ADP-ribose) polymerase 1Humanrucaparib14540.9%No
80268β2-adrenoceptorHumancarazolol33266.2%Yes
80282anaplastic lymphoma receptor tyrosine kinaseHumanbrigatinib14946.4%No
80285anaplastic lymphoma receptor tyrosine kinaseHumanbrigatinib14946.4%No
80292phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gammaHumanCH513279916116.6%No
80328Pim-1 proto-oncogene, serine/threonine kinaseHumanAkt inhibitor X13847.6%No
80334cyclin dependent kinase 5Humanaloisine A10334.9%No
80337glycogen synthase kinase 3 betaHumanalsterpaullone11627.1%No
80348aurora kinase AHumanaurora kinase inhibitor III23084.2%No
80356Pim-1 proto-oncogene, serine/threonine kinaseHumanruboxistaurin14345.5%No
80420glycogen synthase kinase 3 betaHumanGSK-3beta inhibitor VIII12730.4%No
80427protein kinase, cAMP-dependent, catalytic, alpha subunitHumanH-8927879.6%No
80430glycogen synthase kinase 3 betaHumanindirubin-3'-monoxime12729.7%No
80436Janus kinase 2HumanJAK inhibitor I14047.8%No
80437Janus kinase 3HumanJAK inhibitor I12939.1%No
80438tyrosine kinase 2HumanJAK inhibitor I12842.1%No
80504coagulation factor XHumaneribaxaban13657.7%No
80519epidermal growth factor receptorHumanPD 17426511534.1%No
80524phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gammaHumanPI 3-Kg inhibitor15515.9%No
80528phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gammaHumanPI 3-Kg inhibitor II15515.9%No
80549FK506 binding protein 1AHumansirolimus9587.9%Yes
80557cyclin dependent kinase 2Humanseliciclib12541.6%No
80561mitogen-activated protein kinase 14HumanSB22002511830.9%No
80574cyclin dependent kinase 2HumanSU951611538.3%No
80583transforming growth factor beta receptor 1HumanTGF-beta RI kinase inhibitor14142.9%No
80594phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alphaHumanwortmannin70164.2%No
80614mitogen-activated protein kinase 1HumanERK inhibitor II11631.3%No
80623bromodomain containing 2HumanME bromodomain inhibitor6657.0%No
80624bromodomain containing 2HumanET bromodomain inhibitor6657.0%No
80625bromodomain containing 4Humancompound 1 [PMID: 25408830]6038.6%No
80630bromodomain and PHD finger containing 1Humancompound 3 [PMID: 25408830]7663.6%No
80639mitogen-activated protein kinase 14Humantalmapimod13336.5%No
80641mitogen-activated protein kinase 14HumanPH-7978048222.5%No
80658MMP12HumanRXP470.19559.1%No
80672mitogen-activated protein kinase 14HumanBMS-58294913436.3%No
80692Androgen receptorHumanandarine19678.3%No
80705Neutral endopeptidaseHumansacubitrilat61788.3%No
80713Angiotensin-converting enzyme 2HumanMLN-476024339.3%No
80716cyclin dependent kinase 2Humanroniciclib13545.0%No
80719fibroblast growth factor receptor 1HumanBGJ-39815039.0%No
80724Angiotensin-converting enzymeHumanRXP-40724338.5%No
80753AKT serine/threonine kinase 1Humanipatasertib28282.6%No
80759phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gammaHumanapitolisib16316.8%No
80764spleen associated tyrosine kinaseHumanentospletinib13646.4%No
80775ABL proto-oncogene 1, non-receptor tyrosine kinaseHumanbafetinib13545.7%No
807843-phosphoinositide dependent protein kinase 1Human7-hydroxystaurosporine13543.4%No
80797Janus kinase 2Humanfilgotinib14047.8%No
80802SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4HumanPFI-36351.2%No
80808polo like kinase 1HumanNMS-P93713844.1%No
80833mitogen-activated protein kinase kinase 1HumanPD 032590114141.1%No
80835phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alphaHumanPF-0469150216417.2%No
80836aurora kinase AHumandanusertib11641.1%No
80839cyclin dependent kinase 2Humanmilciclib12841.1%No
80845mitogen-activated protein kinase kinase 1Humanrefametinib13739.9%No
80860protein kinase C alphaHumansotrastaurin13738.0%No
80866polo like kinase 1Humanvolasertib12737.6%No
80880Insulin-like growth factor I receptorHumanBMS-75480715448.6%No
80886Janus kinase 2HumanBMS-91154314046.5%No
80974mechanistic target of rapamycinHumanPI-10317314.7%No
80998HCK proto-oncogene, Src family tyrosine kinaseHumanPP12113228.9%No
81001glycogen synthase kinase 3 betaHumanCHIR-9902112729.8%No
81018farnesyltransferase, CAAX box, betaHumantipifarnib26760.9%No
81034ribosomal protein S6 kinase B1HumanPF-470867128181.2%No
81041ribosomal protein S6 kinase A3HumanBI-D187026379.4%No
81051mitogen-activated protein kinase 14HumanVX-74513837.8%No
81064MET proto-oncogene, receptor tyrosine kinaseHumanSGX-52314746.1%No
81065B-Raf proto-oncogene, serine/threonine kinaseHumanGDC-087912136.5%No
81068mitogen-activated protein kinase-activated protein kinase 2HumanPF-364402213841.9%No
81069mitogen-activated protein kinase-activated protein kinase 2HumanPF-364402213841.9%No
81080casein kinase 1 deltaHumanPF-480056713344.6%No
81086CDC like kinase 1HumanKH-CB1915846.6%No
81087CDC like kinase 3HumanKH-CB1915941.5%No
81089mitogen-activated protein kinase 1HumanSCH77298413737.7%No
81091mitogen-activated protein kinase 7HumanXMD8-9212937.0%No
81100phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gammaHumanpictilisib16316.9%No
81104phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gammaHumanAZD648216316.8%No
81109aurora kinase AHumanMK-510811843.5%No
81113TANK binding kinase 1HumanMRT6730714121.2%No
81115polo like kinase 1HumanBI-253612742.9%No
81116polo like kinase 2HumanBI-253623676.3%No
81122Bruton tyrosine kinaseHumanCGI174613950.9%No
81137mitogen-activated protein kinase kinase kinase 7HumanNG-2510031.5%No
81146mitogen-activated protein kinase kinase kinase 7Human5Z-7-oxozeaenol13442.2%No
81169kinase insert domain receptorHumanaxitinib15047.2%Yes
81173B-Raf proto-oncogene, serine/threonine kinaseHumanCHIR-26513347.0%No
81175kinase insert domain receptorHumansorafenib15850.8%Yes
81179epidermal growth factor receptorHumanerlotinib13841.1%Yes
81180epidermal growth factor receptorHumangefitinib13841.6%Yes
81202MET proto-oncogene, receptor tyrosine kinaseHumanforetinib16353.6%No
81205MET proto-oncogene, receptor tyrosine kinaseHumanSGX-52314746.1%No
81210aurora kinase AHumanMLN-805413750.0%No
81211aurora kinase AHumanMLN-805413750.0%No
81212aurora kinase AHumantozasertib13650.6%No
81213aurora kinase BHumantozasertib12542.5%No
81214aurora kinase AHumantozasertib13650.6%No
81218B-Raf proto-oncogene, serine/threonine kinaseHumanPLX-472013347.1%No
81219B-Raf proto-oncogene, serine/threonine kinaseHumanPLX-472013347.1%No
81225KIT proto-oncogene receptor tyrosine kinaseHumansunitinib15947.0%Yes
81286KIT proto-oncogene receptor tyrosine kinaseHumansunitinib15947.0%Yes
81287kinase insert domain receptorHumansunitinib15844.5%Yes
81294spleen associated tyrosine kinaseHumantamatinib12542.6%No
81305kinase insert domain receptorHumansorafenib15850.8%Yes
81311B-Raf proto-oncogene, serine/threonine kinaseHumansorafenib13347.8%Yes
81345Rho associated coiled-coil containing protein kinase 1Humanfasudil28768.9%Yes
81347Rho associated coiled-coil containing protein kinase 1Humanfasudil28768.9%Yes
81366cell division cycle 7HumanXL41312734.9%No
81398SRC proto-oncogene, non-receptor tyrosine kinaseHumanbosutinib13245.8%Yes
81423casein kinase 2, alpha 1 polypeptide subunitHumanCX-494513138.6%No
81435casein kinase 2, alpha 1 polypeptide subunitHumancompound 1a [PMID: 24900749]12537.2%No
81443serine/threonine kinase 10Humanbosutinib26990.8%Yes
81444mitogen-activated protein kinase kinase kinase 5Humancompound 10 [PMID: 23147077]12847.2%No
81449AKT serine/threonine kinase 2HumanGSK69069326077.8%No
81491EPH receptor A3Humancompound 66 [PMID: 19788238]13035.7%No
81500beta adrenergic receptor kinase 1Humanbalanol14120.3%No
81546mitogen-activated protein kinase kinase 6Humanstaurosporine12843.8%No
81547death associated protein kinase 1Humanstaurosporine14351.1%No
81554Rho associated coiled-coil containing protein kinase 1HumanRKI-144728469.0%No
81576Pim-1 proto-oncogene, serine/threonine kinaseHumancompound 20 [PMID: 22136433]14244.9%No
81577Pim-3 proto-oncogene, serine/threonine kinaseHumancompound 20 [PMID: 22136433]14244.9%No
81635IL2 inducible T-cell kinaseHumancompound 7 [PMID: 22464456]13148.9%No
81639mitogen-activated protein kinase kinase kinase 14Humancompound 31 [PMID: 23374866]12835.7%No
81653serine/threonine kinase 24Humanbosutinib12239.2%Yes
81673mitogen-activated protein kinase-activated protein kinase 2Humancompound 16 [PMID: 17480064]13841.0%No
81707Rho associated coiled-coil containing protein kinase 1HumanY2763228768.9%No
81767mechanistic target of rapamycinHumanPP-24217414.7%No
81808transforming growth factor beta receptor 1HumanSB-43154214145.3%No
81842lysine demethylase 6BHumanIOX19227.4%No
81844WD repeat domain 5HumanOICR-942925782.1%No
81847bromodomain adjacent to zinc finger domain 2BHumanGSK28016353.0%No
81848SET domain containing lysine methyltransferase 7Human(R)-PFI-29636.0%No
81854SET and MYND domain containing 2HumanLLY-50711926.8%No
81894amyloid P component, serumHumanCPHPC9144.1%No
81910purine nucleoside phosphorylaseHumanforodesine22577.5%No
81911poly(ADP-ribose) polymerase 1Humanniraparib14540.2%No
81924protein arginine methyltransferase 5 HumanEPZ01566627242.0%No
81928Monoamine oxidase BHumansafinamide33464.0%Yes
81929Monoamine oxidase BHumansafinamide33464.0%Yes
81930squalene synthase Humancompound 15a [PMID: 22464687]27380.0%No
81931MET proto-oncogene, receptor tyrosine kinaseHumanAM712841.0%No
81932leucine rich repeat kinase 2HumanPF-0645458912241.9%No
81938dipeptidyl peptidase 4Humancompound 1 (Xiao et al. 2014)61681.8%No
81939bromodomain adjacent to zinc finger domain 2BHumancompound 1 [PMID: 25719566]6453.8%No
81940bromodomain containing 4Humancompound 7d [PMID: 25703523]6046.5%No
81941bromodomain adjacent to zinc finger domain 2BHumancompound 7 [PMID: 25719566]5848.7%No
81944Janus kinase 2Humandecernotinib13946.9%No
81950CYP11B2Humanfadrozole37377.0%Yes
81953poly(ADP-ribose) polymerase 1Humantalazoparib23061.9%No
81954poly(ADP-ribose) polymerase 2Humantalazoparib23162.5%No
81962BCL2, apoptosis regulatorHumannavitoclax10361.4%No
82033glutaminyl-peptide cyclotransferaseHumanPBD15021665.3%No
82041bromodomain containing 4HumanLY 2940026651.2%No
82072transthyretinHumantafamidis10481.1%Yes
82102bromodomain containing 9HumanI-BRD96863.2%No
82125A2A receptorHumanUK-432,09736073.6%No
82200poly (ADP-ribose) polymerase 3HumanME032822863.6%No
82209B-Raf proto-oncogene, serine/threonine kinaseHumanAZ62811540.6%No
82212glycogen synthase kinase 3 betaHumanAZD285811825.2%No
82339protein arginine methyltransferase 3HumanSGC70722365.3%No
82362bromodomain containing 9HumanLP996652.8%No
82372bromodomain and PHD finger containing 1HumanPFI-48068.1%No
82388M1 receptorHumantiotropium32863.5%Yes
82425LPA1 receptorHumanONO-308057333272.1%No
82426LPA1 receptorHumanONO-978030735576.3%No
82427LPA1 receptorHumanONO-991053935576.3%No
82443insulin degrading enzymeHumanNTE-140841.2%No
82444insulin degrading enzymeHumanNTE-240941.3%No
82445insulin degrading enzymeHumanquinoline 228228.4%No
82448furin, paired basic amino acid cleaving enzymeHumanMI-114821644.6%No
82454fatty acid synthaseHumanGSK219406946970.9%No
82515MMP13Humancompound 15 [PMID: 22017539]11365.5%No
82516aldo-keto reductase family 1 member BHumanAK19828489.6%No
82517CYP17A1Humangaleterone37074.7%No
82521ATPase family, AAA domain containing 2Humancompound 60 [PMID: 26155854]5944.6%No
82602ADAM17HumanIK-86210238.7%No
82636beta-secretase 1Humancompound 16 [PMID: 23412139]32682.3%No
82660CD38Humanisatuximab16062.1%No
82672poly(ADP-ribose) polymerase 2Humancompound 10b [PMID: 26222319]14639.9%No
82673poly(ADP-ribose) polymerase 1Humancompound 10b [PMID: 26222319]12734.8%No
82674ATPase family, AAA domain containing 2Humancompound 33 [PMID: 26230603]7153.8%No
82686bromodomain containing 4HumanRVX 2088371.9%No
82687bromodomain containing 2HumanRVX 2088371.9%No
82690Peroxisome proliferator-activated receptor-γHumanresveratrol7927.2%No
82694lysine demethylase 4AHumancompound 6a [PMID: 18942826]14537.8%No
82695lysine demethylase 4EHumancompound 6a [PMID: 18942826]14540.2%No
82697CYP2D6Humanajmalicine37477.9%Yes
82710CYP2A6Humancompound 39a [PMID: 15634016]37478.4%No
82796retinol binding protein 4HumanA112010147.2%No
82822CYP3A4Humanritonavir37476.9%Yes
82826phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gammaHumancompound 82 [PMID: 21332118]15516.0%No
82830mechanistic target of rapamycinHumancompound 82 [PMID: 21332118]15516.0%No
82842mPGES1Humancompound 30 [PMID: 15953724]10768.8%No
82872RTP Type GHumancompound 1 [PMID: 21882820]8928.4%No
82891mechanistic target of rapamycinHumantorin 217214.6%No
82905MMP1HumanCGS-27023A6135.7%No
82936fibroblast growth factor receptor 4HumanBLU993111939.3%No
82972NOP receptorHumanSB 61211120347.6%No
82981fatty acid binding protein 4MouseHTS0103711385.5%No
83004GluK2Ratkainate17968.2%No
83037DOT1 like histone lysine methyltransferaseHumanbromo-deaza-SAH11326.6%No
83076Rev-Erb-βHumancobalt protoporphyrin IX19296.0%No
83084Retinoic acid receptor-αHumanRo 40-605517163.9%No
83093Peroxisome proliferator-activated receptor-γHumanbexarotene16973.7%Yes
83094Estrogen-related receptor-γHumanGSK518217376.1%No
83095Estrogen-related receptor-γHuman4-hydroxytamoxifen16772.2%No
83096Estrogen receptor-αHuman4-hydroxytamoxifen19376.5%No
83118mitogen-activated protein kinase kinase 1Humancobimetinib14848.8%Yes
83121MET proto-oncogene, receptor tyrosine kinaseHumantepotinib14750.2%No
83128phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gammaHumanAMG31916216.8%No
83160p21 (RAC1) activated kinase 1HumanPF-375830926387.3%No
83169p21 (RAC1) activated kinase 6HumanPF-375830912944.0%No
83171p21 (RAC1) activated kinase 1HumanFRAX59724481.0%No
83183neurotrophic receptor tyrosine kinase 2HumanGW-258012641.8%No
83194B-Raf proto-oncogene, serine/threonine kinaseHumanLY300912012440.1%No
83214bromodomain containing 9HumanBI-95646552.0%No
83226SET and MYND domain containing 2HumanBAY-59815535.6%No
83227protein arginine methyltransferase 5 HumanGSK59128143.4%No
83231protein arginine methyltransferase 6HumanMS02326971.3%No
83232protein arginine methyltransferase 6HumanMS02326971.3%No
83246B-Raf proto-oncogene, serine/threonine kinaseHumanBGB-28313244.9%No
83277phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gammaHumanomipalisib16116.6%No
83291lysine demethylase 5BHumanGSK-J116233.5%No
83383Arginase IHumancompound 9 [PMID: 23472952]17756.1%No
83384Arginase IIHumancompound 9 [PMID: 23472952]17757.5%No
83385indoleamine 2,3-dioxygenase 1HumanNLG91913633.5%No
83479peptidyl arginine deiminase 4Humano-F-amidine29944.4%No
83481Neutral endopeptidaseHumancompound 1a [PMID: 25692029]61287.8%No
83483Leukotriene A4 hydrolaseHumancompound 1a [PMID: 25692029]43069.6%No
83518bromodomain containing 4HumanCPI-06109775.0%No
83541receptor interacting serine/threonine kinase 2HumanGSK58314142.9%No
83546OX1 receptorHumanSB-67404240172.3%No
83551SERTHumanescitalopram40774.0%Yes
83552SERTHumanparoxetine40774.0%Yes
83559Neuronal NOSHumancompound 14j [PMID: 27050842]11527.1%No
83560Neuronal NOSRatcompound 14j [PMID: 27050842]11527.0%No
83605ABL proto-oncogene 1, non-receptor tyrosine kinaseHumanrebastinib13548.4%No
83611epidermal growth factor receptorHumanWZ400212437.2%No
83653κ receptorHumanJDTic36976.7%No
83677transmembrane protein 173Human2'3'-cGAMP10342.1%No
83697mitogen-activated protein kinase 1HumanGDC-099413738.6%No
83711A2A receptorHumancompound 4g [PMID: 22220592]10732.2%No
83738heat shock protein 90 alpha family class A member 1HumanBIIB02113456.1%No
83739heat shock protein 90 alpha family class A member 1HumanSNX072313256.2%No
83743Bruton tyrosine kinaseHumanGDC-083414553.3%No
83753TTK protein kinaseHumanMPS1-IN-113342.2%No